Evidence map›Paper›PMID 29291350›Full record

ArticleNature chemical biology2018

Accessing chemical diversity from the uncultivated symbionts of small marine animals.

Thomas E Smith, Christopher D Pond, Elizabeth Pierce, Zachary P Harmer, Jason Kwan, Malcolm M Zachariah, Mary Kay Harper, Thomas P Wyche, Teatulohi K Matainaho, Tim S Bugni and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
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  9. Bibacillin 1: A two-component lantibiotic frombioRxiv : the preprint server for biology · 2024
    Article
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  16. The mechanism of thia-Michael addition catalyzed by LanC enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Thomas E SmithDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Christopher D PondDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.
Elizabeth PierceDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Zachary P HarmerDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Jason KwanDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Malcolm M ZachariahDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Mary Kay HarperDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Thomas P WychePharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA.
Teatulohi K MatainahoDiscipline of Pharmacology, School of Medicine and Health Sciences, University of Papua New Guinea, National Capital District 111, Papua New Guinea.
Tim S BugniPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA.
Louis R BarrowsDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.
Chris M IrelandDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.
Eric W SchmidtDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA.

Funding

Conservation and Sustainable Use of Biodiversity in PNGU01TW006671 · FIC · UNIVERSITY OF UTAH · PI BARROWS, LOUIS R · 2003 to 2014
$8.8M
Directed posttranslational modifications for drug design and discoveryR01GM102602 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2013 to 2016
$1.4M
Marine symbiotic interactions for discovery of bioactive compoundsR01GM107557 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2013 to 2016
$1.2M
FIC NIH HHS U01 TW006671NIGMS NIH HHS R01 GM102602NIGMS NIH HHS R01 GM107557
6 · The paper itself

Abstract

Chemistry drives many biological interactions between the microbiota and host animals, yet it is often challenging to identify the chemicals involved. This poses a problem, as such small molecules are excellent sources of potential pharmaceuticals, pretested by nature for animal compatibility. We discovered anti-HIV compounds from small, marine tunicates from the Eastern Fields of Papua New Guinea. Tunicates are a reservoir for new bioactive chemicals, yet their small size often impedes identification or even detection of the chemicals within. We solved this problem by combining chemistry, metagenomics, and synthetic biology to directly identify and synthesize the natural products. We show that these anti-HIV compounds, the divamides, are a novel family of lanthipeptides produced by symbiotic bacteria living in the tunicate. Neighboring animal colonies contain structurally related divamides that differ starkly in their biological properties, suggesting a role for biosynthetic plasticity in a native context wherein biological interactions take place.

Indexed as

Drug DiscoveryMicrobiotaSymbiosisAnimalsAnti-HIV AgentsBacteriaBiological ProductsDNADrug Evaluation, PreclinicalGenomicsHIV InfectionsHumansLysinoalanineMetagenomeMetagenomicsMultigene FamilyAnti-HIV AgentsBiological ProductsDNALysinoalaninePeptides

Identifiers

PMID29291350
PMCPMC5771842

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.