ArticleNature chemical biology2018
An OPR3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis.
Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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124 citing papers in PubMed, 256 citations in OpenAlex.
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- The root-knot nematode effector Mi1D08B targets a NINJA-family co-repressor to suppress jasmonate production and promote infection in soybean.The Plant journal : for cell and molecular biology · 2026Article
- Size of chloroplasts in Arabidopsis mesophyll cells affects jasmonate biosynthesis.Plant biology (Stuttgart, Germany) · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Unveiling tomato defense mechanisms against Bradysia impatiens (Diptera: Sciaridae) feeding: insights from transcriptomic and metabolomic analyses.BMC plant biology · 2026Article
- Mechanisms underlying the response of different resistant quinoa cultivars to Spodoptera exigua feeding.BMC plant biology · 2026Article
- Jasmonate Biosynthesis Across Bryophyte Lineages: Lessons fromPlants (Basel, Switzerland) · 2026Review
- Evolutionary shifts in plant adaptation mediated by phytohormones.Plant communications · 2026Review
- Transcending the jasmonate-mediated growth-defense trade-off: Pathways to unlocking plant potential.Plant communications · 2026Review
- Phytohormonal and Transcriptomic Mechanisms of Multigenerational Stress Memory in Wheat Under Weed Competition.Plant, cell & environment · 2026Article
- Sodium Hydrosulfide (NaHS) Triggers Jasmonate and Reactive Oxygen Species to Boost Rice (Plants (Basel, Switzerland) · 2026Article
- Differential Jasmonate Profiles in Oat Roots and Leaves Reveal a Role for 12-Oxo Phytodienoic Acid (OPDA) in Drought Tolerance by Modulating Root Growth.Plants (Basel, Switzerland) · 2026Article
- Molecular insights into volatile organic compound sensing and signaling in plants.The Plant journal : for cell and molecular biology · 2026Review
- Transcription Factor PFB1 Is Required for the Botrytis cinerea Effector BcSCR1-Mediated Pathogenesis.Molecular plant pathology · 2026Article
- Genome-Wide Identification of theBiology · 2025Article
- Strigolactones modulate jasmonate-dependent transcriptional reprogramming during wound signalling in Arabidopsis.Journal of applied genetics · 2025Article
- Robustness in jasmonate signaling: mechanisms of concerted regulation and implications for crop improvement.aBIOTECH · 2025Review
- Spatiotemporal localization of jasmonate in the regulation of fruit set in tomato.Journal of experimental botany · 2025Article
- Multiomics analysis revealed the temporally common and specific molecular changes in Arabidopsis thaliana (L.) under salt stress.BMC genomics · 2025Article
64 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosynthesis of the phytohormone jasmonoyl-isoleucine (JA-Ile) requires reduction of the JA precursor 12-oxo-phytodienoic acid (OPDA) by OPDA reductase 3 (OPR3). Previous analyses of the opr3-1 Arabidopsis mutant suggested an OPDA signaling role independent of JA-Ile and its receptor COI1; however, this hypothesis has been challenged because opr3-1 is a conditional allele not completely impaired in JA-Ile biosynthesis. To clarify the role of OPR3 and OPDA in JA-independent defenses, we isolated and characterized a loss-of-function opr3-3 allele. Strikingly, opr3-3 plants remained resistant to necrotrophic pathogens and insect feeding, and activated COI1-dependent JA-mediated gene expression. Analysis of OPDA derivatives identified 4,5-didehydro-JA in wounded wild-type and opr3-3 plants. OPR2 was found to reduce 4,5-didehydro-JA to JA, explaining the accumulation of JA-Ile and activation of JA-Ile-responses in opr3-3 mutants. Our results demonstrate that in the absence of OPR3, OPDA enters the β-oxidation pathway to produce 4,5-ddh-JA as a direct precursor of JA and JA-Ile, thus identifying an OPR3-independent pathway for JA biosynthesis.
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