Evidence map›Paper›PMID 29291022›Full record

ArticleOncotarget2017

NFE2L2/NRF2 silencing-inducible miR-206 targets c-MET/EGFR and suppresses BCRP/ABCG2 in cancer cells.

Bo-Hyun Choi, Da Young Ryu, In-Geun Ryoo, Mi-Kyoung Kwak

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. [Predictive Value of miRNAs Markers for Advanced Lung Squamous Cell Carcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Role of NRF2 in Ovarian Cancer.Antioxidants (Basel, Switzerland) · 2022
    Review
  10. Review
  11. Article
  12. Multidrug efflux transporter ABCG2: expression and regulation.Cellular and molecular life sciences : CMLS · 2021
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Transcription factor-mediated regulation of the BCRP/Expert opinion on drug metabolism & toxicology · 2020
    Review
  18. Article
  19. Potential Applications of NRF2 Inhibitors in Cancer Therapy.Oxidative medicine and cellular longevity · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bo-Hyun ChoiDepartment of Pharmacy and BK21 PLUS Team for Creative Leader Program for Pharmacomics-Based Future Pharmacy, Graduate School of The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
Da Young RyuDepartment of Pharmacy and BK21 PLUS Team for Creative Leader Program for Pharmacomics-Based Future Pharmacy, Graduate School of The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
In-Geun RyooDepartment of Pharmacy and BK21 PLUS Team for Creative Leader Program for Pharmacomics-Based Future Pharmacy, Graduate School of The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
Mi-Kyoung KwakDepartment of Pharmacy and BK21 PLUS Team for Creative Leader Program for Pharmacomics-Based Future Pharmacy, Graduate School of The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
Catholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/NRF2) plays a critical role in the expression of multiple antioxidant and detoxifying enzymes. Herein, we provide evidence of the molecular links between NRF2 and oncogenic signaling hepatocyte growth factor receptor (HGFR/c-MET) and epidermal growth factor receptor (EGFR). Interfering RNA-induced stable inhibition of

Indexed as

BCRP/ABCG2epidermal growth factor receptor (EGFR)hepatocyte growth factor receptor (HGFR/c-MET)microRNA-206 (miR-206)NFE2L2/NRF2

Identifiers

PMID29291022
PMCPMC5739807
OpenAlexW2770922541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.