Evidence map›Paper›PMID 29290954›Full record

ArticleOncotarget2017

WEE1 epigenetically modulates 5-hmC levels by pY37-H2B dependent regulation of

Nupam P Mahajan, Pavani Malla, Shambhavi Bhagwat, Vasundhara Sharma, Amod Sarnaik, Jongphil Kim, Shari Pilon-Thomas, Jeffery Weber, Kiran Mahajan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nupam P MahajanDepartment of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.
Pavani MallaDepartment of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.
Shambhavi BhagwatDepartment of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.
Vasundhara SharmaDepartment of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.
Amod SarnaikDepartment of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Jongphil KimDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL 33612, USA.
Shari Pilon-ThomasDepartment of Immunology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Jeffery WeberLaura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016, USA.
Kiran MahajanDepartment of Tumor Biology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Moffitt Cancer Center · USUniversity of South Florida · USNYU Langone Health · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Targeting a Novel Epigenetic Signaling Nexus ACK1-pY88H4-AR/AR-V7 in Drug Resistant Metastatic Prostate CancerR01CA208258 · NCI · WASHINGTON UNIVERSITY · PI MAHAJAN, NUPAM P · 2017 to 2021
$1.7M
Ack1: A Critical Regulator of Hormone-Refractory Prostate CancerR01CA135328 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI MAHAJAN, NUPAM P · 2010 to 2014
$1.6M
Co-Stimulation to Enhance Adoptive Cell Therapy for Metastatic MelanomaK23CA178083 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SARNAIK, AMOD · 2013 to 2017
$826k
NCI NIH HHS K23 CA178083NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA135328NCI NIH HHS R01 CA208258
6 · The paper itself

Abstract

Epigenetic signaling networks dynamically regulate gene expression to maintain cellular homeostasis. Previously, we uncovered that WEE1 phosphorylates histone H2B at tyrosine 37 (pY37-H2B) to negatively regulate global histone transcriptional output. Although pY37-H2B is readily detected in cancer cells, its functional role in pathogenesis is not known. Herein, we show that WEE1 deposits the pY37-H2B marks within the tumor suppressor gene, isocitrate dehydrogenase 2 (

Indexed as

histone H2BIDH2tyrosine kinasetyrosine phosphorylationWEE1

Identifiers

PMID29290954
PMCPMC5739739
OpenAlexW2767821869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.