ArticleWorld journal of emergency medicine2018
Dose-related effects of dexmedetomidine on immunomodulation and mortality to septic shock in rats.
Article in World journal of emergency medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05641064 (Evaluation of Intraoperative Dexmedetomidine Use on Reducing Inflammatory Response Caused by Cardiopulmonary Bypass in Patients Undergoing Surgical Aortic Valve Replacement), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Intraoperative Dexmedetomidine Use on Reducing Inflammatory Response Caused by Cardiopulmonary Bypass in Patients Undergoing Surgical Aortic Valve Replacement
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Is dexmedetomidine superior to non-dexmedetomidine sedatives (particularly propofol) for sedation in critically ill patients with septic shock? A systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2025Pooled it
- Efficacy of dexmedetomidine for treatment of patients with sepsis: A meta-analysis of randomized controlled trials.Medicine · 2019Pooled it
- Dexmedetomidine Exerts Multi-level Effects to Ameliorate Alzheimer's Disease Pathology in the Adult Zebrafish Brain.Molecular neurobiology · 2026Article
- Dose-related effects of dexmedetomidine on wound healing: evaluating fibroblast activation, collagen synthesis, and prolidase activity.Irish journal of medical science · 2026Article
- Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine.Cardiovascular drugs and therapy · 2024Review
- Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study.Frontiers in pharmacology · 2024Article
- Role of dexmedetomidine in modifying immune paralysis in patients with septic shock: randomized controlled trial.Intensive care medicine experimental · 2023Article
- Dexmedetomidine protects against endothelial injury in septic rats induced by cecal ligation and puncture by decreasing angiopoietin 2 and increasing vascular endothelial cadherin levels.Experimental and therapeutic medicine · 2021Article
- Dexmedetomidine Alleviates LPS-Induced Neuronal Dysfunction by Modulating the AKT/GSK-3β/CRMP-2 Pathway in Hippocampal Neurons.Neuropsychiatric disease and treatment · 2021Article
- Effect of neutrophil CD64 for diagnosing sepsis in emergency department.World journal of emergency medicine · 2020Article
- Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation.Molecular medicine reports · 2019Article
- Hypothermic properties of dexmedetomidine provide neuroprotection in rats following cerebral ischemia-reperfusion injury.Experimental and therapeutic medicine · 2019Article
- Dose-related effects of dexmedetomidine on immunomodulation and mortality to septic shock in rats.World journal of emergency medicine · 2018Article
- Dose-related effects of dexmedetomidine on sepsis-initiated lung injury in rats.Brazilian journal of anesthesiology (Elsevier)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDexmedetomidine has already been used in septic patients as a new sedative agent, few studies have examined its effects on immunomodulation. Therefore, the authors have designed a controlled experimental study to characterize the immunomodulation effects of dexmedetomidine in the cecal ligation and puncture (CLP) model in rats.
methodsAfter CLP, 48 Wistar rats were randomly allocated into four groups: (1) CLP group; (2) small-dose treatment group (2.5 μg·kg
resultsThe HLA-DR level, inflammatory mediator levels, MAP and HR had no obvious changes among Dexmedetomidine treatment groups (DEX groups). Compared with the CLP group, the DEX groups exhibited decreased HLA-DR levels (
conclusionDexmedetomidine treatment in the setting of a CLP sepsis rat model has partially induced immunomodulation that was initiated within 5 h, causing a decreased HR while maintaining MAP, remarkably improving metabolic acidosis and improving mortality dose-dependently.
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Registered trials
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