Evidence map›Paper›PMID 29290818›Full record

ArticleTheranostics2018

Methylation-associated silencing of

Kangmei Chen, Michelle Xin Liu, Celia Sze-Ling Mak, Mingo Ming-Ho Yung, Thomas Ho-Yin Leung, Dakang Xu, Siew-Fei Ngu, Karen Kar-Loen Chan, Huijuan Yang, Hextan Yuen-Sheung Ngan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
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  7. Review
  8. ZEPPI: Proteome-scale sequence-based evaluation of protein-protein interaction models.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Pan-inhibition of the three HCancer cell international · 2024
    Article
  10. Article
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  13. Article
  14. MiR-630 suppresses non-small cell lung cancer by targeting vimentin.Journal of clinical laboratory analysis · 2022
    Article
  15. Review
  16. Article
  17. Mig-6 Inhibits Autophagy in HCC Cell Lines by Modulating miR-193a-3p.International journal of medical sciences · 2022
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kangmei ChenDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Michelle Xin LiuDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Celia Sze-Ling MakDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Mingo Ming-Ho YungDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Thomas Ho-Yin LeungDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Dakang XuFaculty of Medical Laboratory Science, Rujin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.
Siew-Fei NguDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Karen Kar-Loen ChanDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Huijuan YangDepartment of Gynecological Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China.
Hextan Yuen-Sheung NganDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
David Wai ChanDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
University of Hong Kong · HKChinese University of Hong Kong · CNShanghai Jiao Tong University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading to the upregulation of GRB7 remain largely unknown. Here, we propose that the epigenetic modification of GRB7 at the post-transcriptional level may be a crucial factor leading to GRB7 upregulation in ovarian cancers.

Indexed as

AnimalsCarcinogenesisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticGene SilencingGRB7 Adaptor ProteinHumansMAP Kinase Signaling SystemMethylationMiceMice, Inbred BALB CMice, NudeMicroRNAsGRB7 Adaptor ProteinGRB7 protein, humanMicroRNAsMIRN193 microRNA, humanDNA hypermethylationGRB7MAPK signalingmiR-193a-3povarian cancer.

Identifiers

PMID29290818
PMCPMC5743558
OpenAlexW2770335217

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.