Evidence map›Paper›PMID 29290791›Full record

ArticleTheranostics2018

A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells.

Haoran Liu, Junhua Mai, Jianliang Shen, Joy Wolfram, Zhaoqi Li, Guodong Zhang, Rong Xu, Yan Li, Chaofeng Mu, Youli Zu and 8 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Advantages, applications, and future directions ofMolecular therapy. Nucleic acids · 2025
    Review
  3. Nanotechnology Applications in Breast Cancer Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2024
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  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery.Advanced materials (Deerfield Beach, Fla.) · 2020
    Review
  17. Tumor Targeted Nanocarriers for Immunotherapy.Molecules (Basel, Switzerland) · 2020
    Review
  18. Article
  19. Article
  20. Lipoprotein-based drug delivery.Advanced drug delivery reviews · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Haoran LiuCollege of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Junhua MaiDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Jianliang ShenDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Joy WolframDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Zhaoqi LiDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Guodong ZhangDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Rong XuDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yan LiDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Chaofeng MuDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Youli ZuDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Xin LiInstitute of Molecular Medicine and the Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, USA.
Ganesh L LokeshInstitute of Molecular Medicine and the Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, USA.
Varatharasa ThiviyanathanInstitute of Molecular Medicine and the Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, USA.
David E VolkInstitute of Molecular Medicine and the Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, USA.
David G GorensteinInstitute of Molecular Medicine and the Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, USA.
Mauro FerrariDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Zhongbo HuCollege of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Haifa ShenDepartment of Nanomedicine, Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.
Houston Methodist · USThe University of Texas Health Science Center at Houston · USMethodist Hospital · USCornell University · USMayo Clinic in Florida · USUniversity of Chinese Academy of Sciences · CNWeill Cornell Medicine · US

Funding

Transport Oncophysics CoreU54CA210181 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WANG, RONGFU · 2016 to 2020
$9.3M
Tumor vasculature-targeted nanotherapeutics for DNA damage responseR01CA193880 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI SHEN, HAIFA · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA193880NCI NIH HHS U54 CA210181
6 · The paper itself

Abstract

Aptamers have the potential to be used as targeting ligands for cancer treatment as they form unique spatial structures.

Indexed as

A549 CellsAnimalsAptamers, NucleotideCD11b AntigenCell Line, TumorDoxorubicinFemaleHumansMCF-7 CellsMiceMice, Inbred BALB CMice, NudeMyeloid-Derived Suppressor CellsPolyethylene GlycolsReceptors, ChemokineAptamers, NucleotideCD11b AntigenDoxorubicinliposomal doxorubicinPolyethylene GlycolsReceptors, Chemokineactive targetingDNA aptamerliposomemyeloid-derived suppressor cells (MDSCs)tumor microenvironment

Identifiers

PMID29290791
PMCPMC5743458
OpenAlexW2767051800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.