Evidence map›Paper›PMID 29290790›Full record

ArticleTheranostics2018

Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging.

Philipp Mayer, Christine Dinkic, Ralf Jesenofsky, Miriam Klauss, Peter Schirmacher, Ulrike Dapunt, Thilo Hackert, Florian Uhle, G Maria Hänsch, Matthias M Gaida

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Lipid metabolism and tumor immunotherapy.Frontiers in cell and developmental biology · 2023
    Review
  4. Review
  5. Neutrophils in cancer carcinogenesis and metastasis.Journal of hematology & oncology · 2021
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. An Immunological Glance on Pancreatic Ductal Adenocarcinoma.International journal of molecular sciences · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. The function of TRP channels in neutrophil granulocytes.Pflugers Archiv : European journal of physiology · 2018
    Review
  19. The Role of TRP Channels in the Metastatic Cascade.Pharmaceuticals (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Philipp MayerClinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Christine DinkicClinic for Gynecology and Obstetrics, University Hospital Heidelberg, Heidelberg, Germany.
Ralf JesenofskyClinic for Internal Medicine II, University Hospital Mannheim, Medical Faculty Heidelberg, Mannheim, Germany.
Miriam KlaussClinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Peter SchirmacherInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Ulrike DapuntClinic for Orthopedics and Trauma Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Thilo HackertDepartment of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Florian UhleClinic for Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.
G Maria HänschInstitute of Immunology, University Heidelberg, Heidelberg, Germany.
Matthias M GaidaInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion-weighted magnetic resonance imaging (DW-MRI), and to further asses the underlying mechanisms.

Indexed as

ActinsCell Line, TumorCell ProliferationDiffusion Magnetic Resonance ImagingHumansImmunohistochemistryMatrix Metalloproteinase 9Models, BiologicalNeutrophilsPancreatic NeoplasmsPancreatic Stellate CellsACTA2 protein, humanActinsMatrix Metalloproteinase 9azurocidindesmoplastic stromadiffusion-weighted magnetic resonance imagingpancreatic cancerstellate cellstumor infiltrating neutrophils

Identifiers

PMID29290790
PMCPMC5743457
OpenAlexW2765214976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.