ArticleMolecular cell2018
Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response.
Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 225 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
225 citing papers in PubMed, 1 synthesis or guideline pooled it, 607 citations in OpenAlex.
- Dry side of the core: a meta-analysis addressing the original nature of the ABA signalosome at the onset of seed imbibition.Frontiers in plant science · 2023Pooled it
- Active ROP2 triggers leaf senescence and orchestrates the growth-senescence trade-off under nitrogen starvation.Plant signaling & behavior · 2026Article
- Review
- From activation to desensitization: How ABA balances plant growth and abiotic stress response?Plant communications · 2026Review
- E3 ligase ATL17 is a key regulator of abscisic acid signaling that mediates AHG1 degradation in Arabidopsis thaliana.The New phytologist · 2026Article
- Glucose-TOR Signaling Regulates Root Hair Elongation inPlants (Basel, Switzerland) · 2026Article
- SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling.Plant physiology · 2026Article
- Duet between sugars and hormones: The molecular dialogue fine-tuning hypoxia acclimation in plants.Journal of integrative plant biology · 2026Review
- A Water-Saving Drought Survival Phenotype in a Wheat TILLING Mutant Involves Survival-Biased Metabolic and Phosphorylation Reprogramming.Plant, cell & environment · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- The ALS-associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle.The FEBS journal · 2026Article
- Over-expression transcription factor ERF1 promotes seed germination by enhancing mitochondrial function.Plant cell reports · 2026Article
- Plant Immunometabolism: Metabolic Reprogramming Linking Developmental Signaling and Defense Metabolites.International journal of molecular sciences · 2026Review
- The RCAR12-CAP1-OST1 module controls ABA-mediated stomatal closure in Arabidopsis.PLoS genetics · 2026Article
- Dynamic Coordination: How ERF Transcription Factors Coordinate Plant Development and Adaptive Stress Responses.Biomolecules · 2026Review
- Article
- Decoding the growth-defense dialectic: TOR signaling and developmental genetics in maize.Journal of experimental botany · 2026Review
- OsDi19-1 Acts Downstream of OsABI5 to Negatively Regulate ABA-Inhibited Seed Germination and Seedling Growth in Rice.Rice (New York, N.Y.) · 2026Article
- SWEET1-mediated glucose transport is crucial for energy availability in Arabidopsis.The New phytologist · 2026Article
- The Transcription Factors NFYA1 and GBF3 Jointly Regulate CHS2 to Promote Tangeretin Accumulation and Cold Tolerance in Citrus.Plant biotechnology journal · 2026Article
165 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we discovered that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants. This phosphorylation disrupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2 kinases. Under stress, ABA-activated SnRK2s phosphorylate Raptor, a component of the TOR complex, triggering TOR complex dissociation and inhibition. Thus, TOR signaling represses ABA signaling and stress responses in unstressed conditions, whereas ABA signaling represses TOR signaling and growth during times of stress. Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.