Evidence map›Paper›PMID 29290586›Full record

ArticleDevelopmental cell2018

Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.

Alex J Hughes, Hikaru Miyazaki, Maxwell C Coyle, Jesse Zhang, Matthew T Laurie, Daniel Chu, Zuzana Vavrušová, Richard A Schneider, Ophir D Klein, Zev J Gartner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 186 citations in OpenAlex.

  1. Discrete 2D Material Programming for 3D Shaping and Morphogenesis-Inspired 4D Bioprinting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alex J HughesDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA; Center for Cellular Construction, University of California, San Francisco, CA 94143, USA.
Hikaru MiyazakiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA; Graduate Program in Bioengineering, University of California, Berkeley, CA, USA; Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA 94143, USA.
Maxwell C CoyleDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Jesse ZhangDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA; Graduate Program in Bioengineering, University of California, Berkeley, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
Matthew T LaurieDepartment of Biochemistry and Molecular Biology, University of California, San Francisco, CA 94143, USA.
Daniel ChuDepartment of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA.
Zuzana VavrušováDepartment of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA.
Richard A SchneiderDepartment of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA.
Ophir D KleinProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, CA 94143, USA.
Zev J GartnerDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA; Center for Cellular Construction, University of California, San Francisco, CA 94143, USA; Graduate Program in Bioengineering, University of California, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: zev.gartner@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

TEMPORAL REGULATION OF CRANIAL SKELETOGENESISR01DE016402 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RICHARD A SCHNEIDER · 2004 to 2026
$8.2M
Total synthesis of the human mammary glandDP2HD080351 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN · 2013 to 2013
$2.4M
Mechanisms of Secondary Cartilage Induction and Maintenance in the JawR01DE025668 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHNEIDER, RICHARD A · 2016 to 2020
$2.0M
Macro Confocal Microscope System for Large-Scale Imaging in Basic and Translational BiologyS10OD021664 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHNEIDER, RICHARD A · 2016 to 2016
$377k
NICHD NIH HHS DP2 HD080351NIDCR NIH HHS R01 DE016402NIDCR NIH HHS R01 DE025668NIH HHS S10 OD021664
6 · The paper itself

Abstract

Many tissues fold into complex shapes during development. Controlling this process in vitro would represent an important advance for tissue engineering. We use embryonic tissue explants, finite element modeling, and 3D cell-patterning techniques to show that mechanical compaction of the extracellular matrix during mesenchymal condensation is sufficient to drive tissue folding along programmed trajectories. The process requires cell contractility, generates strains at tissue interfaces, and causes patterns of collagen alignment around and between condensates. Aligned collagen fibers support elevated tensions that promote the folding of interfaces along paths that can be predicted by modeling. We demonstrate the robustness and versatility of this strategy for sculpting tissue interfaces by directing the morphogenesis of a variety of folded tissue forms from patterns of mesenchymal condensates. These studies provide insight into the active mechanical properties of the embryonic mesenchyme and establish engineering strategies for more robustly directing tissue morphogenesis ex vivo.

Indexed as

Tissue EngineeringAnimalsChick EmbryoExtracellular MatrixFinite Element AnalysisIntestinesMesodermMiceSkinintestinal villimechanobiologymesenchymal condensationsmart materialssoft mattersoft roboticssynthetic biologytissue engineeringtissue folding

Identifiers

PMID29290586
PMCPMC5826757
OpenAlexW2779507783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.