Evidence map›Paper›PMID 29290471›Full record

ArticleTrends in biochemical sciences2018

Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination.

Harshad Ghodke, Jacob S Lewis, Antoine M van Oijen

Abstract readComment
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In one paragraph

Article in Trends in biochemical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Harshad GhodkeSchool of Chemistry, University of Wollongong, Northfields Ave, Wollongong, Australia, 2522; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, Australia, 2522; These authors contributed equally to this work.
Jacob S LewisSchool of Chemistry, University of Wollongong, Northfields Ave, Wollongong, Australia, 2522; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, Australia, 2522; These authors contributed equally to this work.
Antoine M van OijenSchool of Chemistry, University of Wollongong, Northfields Ave, Wollongong, Australia, 2522; Illawarra Health and Medical Research Institute, Northfields Ave, Wollongong, Australia, 2522. Electronic address: vanoijen@uow.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells use a suite of specialized enzymes to repair chromosomal double-strand breaks (DSBs). Two recent studies describe how single-molecule fluorescence imaging techniques are used in the direct visualization of some of the key molecular steps involved. De Tullio et al. and Kaniecki et al. watch individual Srs2 helicase molecules disrupt repair intermediates formed by RPA, Rad51, and Rad52 on DNA during homologous recombination.

Indexed as

Saccharomyces cerevisiaeDNA HelicasesDNA RepairHomologous RecombinationRad51 RecombinaseSaccharomyces cerevisiae ProteinsDNA HelicasesRad51 RecombinaseSaccharomyces cerevisiae ProteinsSRS2 protein, S cerevisiae

Identifiers

PMID29290471

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.