Evidence map›Paper›PMID 29290419›Full record

ArticleInternational journal of cardiology2018

Muscarinic type-1 receptors contribute to I

Jordi Heijman, Dorit Kirchner, Franziska Kunze, Eva Maria Chrétien, Martina B Michel-Reher, Niels Voigt, Michael Knaut, Martin C Michel, Ursula Ravens, Dobromir Dobrev

Open access · greenAbstract read
In one paragraph

Article in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. On indirect negative inotropic effects of muscarine in the isolated human atrium.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  3. Article
  4. Gene Therapies in Atrial Fibrillation.Journal of cardiovascular translational research · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jordi HeijmanInstitute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany; Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Dorit KirchnerDepartment of Pharmacology and Toxicology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany.
Franziska KunzeDepartment of Pharmacology and Toxicology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany.
Eva Maria ChrétienDepartment of Pharmacology and Toxicology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany.
Martina B Michel-ReherDepartment of Pharmacology, Johannes Gutenberg University, Mainz, Germany.
Niels VoigtInstitute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
Michael KnautHeart Surgery, Heart Center Dresden, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany.
Martin C MichelDepartment of Pharmacology, Johannes Gutenberg University, Mainz, Germany.
Ursula RavensDepartment of Pharmacology and Toxicology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany; Institute of Experimental Cardiovascular Medicine, University Heart Center Freiburg-Bad Krozingen, Freiburg, Germany.
Dobromir DobrevInstitute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany; Department of Pharmacology and Toxicology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany. Electronic address: Dobromir.Dobrev@uk-essen.de.
University Hospital Carl Gustav Carus · DEJohannes Gutenberg University Mainz · DEWest German Heart and Vascular Center Essen · DEMaastricht University · NLUniversitäts-Herzzentrum Freiburg-Bad Krozingen · DE

Funding

Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
NHLBI NIH HHS R01 HL131517
6 · The paper itself

Abstract

backgroundBasal and acetylcholine-gated inward-rectifier K METHODS AND

resultsM

conclusionOur data suggest that G

Indexed as

AcetylcholineAtrial FibrillationCells, CulturedChronic DiseaseDose-Response Relationship, DrugHeart AtriaHumansMuscarinic AntagonistsMyocytes, CardiacPotassium Channels, Inwardly RectifyingReceptor, Muscarinic M1Up-RegulationAcetylcholineMuscarinic AntagonistsPotassium Channels, Inwardly RectifyingReceptor, Muscarinic M1Atrial fibrillationInward-rectifier K(+)-channelMuscarinic receptor subtypes

Identifiers

PMID29290419
PMCPMC5815374
OpenAlexW2779473463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.