Evidence map›Paper›PMID 29290213›Full record

ArticleMaturitas2018

Sex hormone levels and change in left ventricular structure among men and post-menopausal women: The Multi-Ethnic Study of Atherosclerosis (MESA).

Vinita Subramanya, Di Zhao, Pamela Ouyang, Joao A Lima, Dhananjay Vaidya, Chiadi E Ndumele, David A Bluemke, Sanjiv J Shah, Eliseo Guallar, Chike C Nwabuo and 4 more

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In one paragraph

Article in Maturitas, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Vinita SubramanyaDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: vsubram4@jhmi.edu.
Di ZhaoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: dizhao@jhu.edu.
Pamela OuyangDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: pouyang@jhmi.edu.
Joao A LimaDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: jlima@jhmi.edu.
Dhananjay VaidyaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: dvaidya1@jhmi.edu.
Chiadi E NdumeleDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: cndumel2@jhmi.edu.
David A BluemkeDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison WI, USA. Electronic address: DBluemke@uwhealth.org.
Sanjiv J ShahDivision of Cardiology, Northwestern School of Medicine, Chicago, IL, USA. Electronic address: sanjiv.shah@northwestern.edu.
Eliseo GuallarDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: eguallar@jhu.edu.
Chike C NwabuoDepartment of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, USA. Electronic address: chikenwabuo@yahoo.com.
Matthew A AllisonDivision of Preventive Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: mallison@ucsd.edu.
Susan R HeckbertCardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA. Electronic address: heckbert@uw.edu.
Wendy S PostDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: wpost@jhmi.edu.
Erin D MichosDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: edonnell@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USHarvard University · USNorthwestern Medicine · USUniversity of California, San Diego · USUniversity of Washington · USUniversity of Wisconsin–Madison · US

Funding

Transition from Risk Factors to Early HF: Prevalence, Pathogenesis, and PhenomicsR01HL127028 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD, SHAH, SANJIV J · 2015 to 2018
$6.5M
Study of Cardiac Mechanics in Systemic HypertensionR01HL107577 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHAH, SANJIV J · 2011 to 2019
$4.1M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
Serum Sex Hormone Levels and Subclinical AtherosclerosisR01HL074338 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GAPSTUR, SUSAN M · 2003 to 2006
$1.1M
Serum Sex Hormonoe Levels &Subclinical AtherosclerosisR01HL074406 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI OUYANG, PAMELA · 2003 to 2006
$1.0M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL074338NHLBI NIH HHS R01 HL074406NHLBI NIH HHS R01 HL107577NHLBI NIH HHS R01 HL127028
6 · The paper itself

Abstract

objectiveSex hormone (SH) levels may contribute to sex differences in the risk of heart failure with preserved ejection fraction (HFpEF). We examined the associations of SH levels with left ventricular mass (LVM) and mass (M):volume (V) ratio, which are risk markers for HFpEF. STUDY

designWe studied 1941 post-menopausal women and 2221 men, aged 45-84 years, participating in the Multi-Ethnic Study of Atherosclerosis (MESA). Serum SH levels, cardiac magnetic resonance imaging (MRI) and ejection fraction (EF) ≥50% had been recorded at baseline (2000-2002). Of these participants, 2810 underwent repeat MRI at Exam 5 (2010-2012). Stratified by sex, linear mixed-effect models were used to test associations between SH and sex hormone binding globulin (SHBG) level [per 1 SD greater log-transformed (SH)] with baseline and change in LV structure. Models were adjusted for age, race/ethnicity, center, height, weight, education, physical activity and smoking, and, in women, for hormone therapy and years since menopause.

main outcome measuresLVM and M:V ratio.

resultsAfter a median of 9.1 years, higher free testosterone levels were independently associated with a modest increase in LVM (g/yr) in women [0.05 (95% CI 0.01, 0.10)] and men [0.16 (0.03, 0.28)], while higher SHBG levels were associated with less LVM change (g/yr) in women [-0.07 (-0.13, -0.01)] and men [-0.15 (-0.27, -0.02)]. In men, higher dehydroepiandrosterone and estradiol levels were associated with increased LVM. Among women, free testosterone levels were positively and SHBG levels inversely associated with change in M:V ratio.

conclusionA more androgenic profile (higher free testosterone and lower SHBG levels) is associated with a greater increase in LVM in men and women and greater increase in M:V ratio in women over the course of 9 years.

Indexed as

AgedAged, 80 and overAndrogensAtherosclerosisEstrogensEthnicityFemaleGonadal Steroid HormonesHeart VentriclesHumansMaleMiddle AgedPostmenopauseRacial GroupsSex Hormone-Binding GlobulinAndrogensEstrogensGonadal Steroid HormonesSex Hormone-Binding GlobulinCardiac magnetic resonance imagingEpidemiologyLeft ventricular remodelingSex differencesSex hormones

Identifiers

PMID29290213
PMCPMC5752123
OpenAlexW2767285808

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.