ReviewMolecular biotechnology2018
Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production.
Review in Molecular biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Chemical Ontogeny in Plants: Developmental Dynamics of Specialized Metabolism and Implications for Ecology, Quality Control, and Bioprospecting.Plants (Basel, Switzerland) · 2026Review
- EfficientInternational journal of molecular sciences · 2025Article
- Localization of Secondary Metabolites in Relict Gymnosperms of the GenusLife (Basel, Switzerland) · 2024Article
- Organic extracts from sustainable hybrid poplar hairy root cultures as potential natural antimicrobial and antibiofilm agents.Protoplasma · 2024Article
- Selenium Nanoparticle and Melatonin Treatments Improve Melon Seedling Growth by Regulating Carbohydrate and Polyamine.International journal of molecular sciences · 2024Article
- Genome-wide identification and characterization of wall-associated kinases, molecular docking and polysaccharide elicitation of monoterpenoid indole alkaloids in micro-propagated Catharanthus roseus.Journal of plant research · 2024Article
- Production of benzylglucosinolate in genetically engineered carrot suspension cultures.Plant biotechnology (Tokyo, Japan) · 2022Article
- Improving galegine production in transformed hairy roots of Galega officinalis L. via elicitation.AMB Express · 2022Article
- Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications.Molecules (Basel, Switzerland) · 2022Review
- Histochemical Localization of Phenolic Compounds and Reactive Oxygen Species in Eucalypt Microcuttings.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Non-target molecular network and putative genes of flavonoid biosynthesis inFrontiers in plant science · 2022Article
- PlantsFrontiers in plant science · 2022Review
- Article
- The Interface amongst Conserved and Specialized Pathways in Non-Paclitaxel and Paclitaxel AccumulatingMetabolites · 2021Article
- Evolution-aided engineering of plant specialized metabolism.aBIOTECH · 2021Review
- Strategies to Modulate Specialized Metabolism in Mediterranean Crops: From Molecular Aspects to Field.International journal of molecular sciences · 2021Review
- Utilizing Plant Synthetic Biology to Improve Human Health and Wellness.Frontiers in plant science · 2021Review
- Effect of methyl jasmonate and salicylic acid on the production of metabolites in cell suspensions cultures ofBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Comparative transcriptome analysis of a taxol-producing endophytic fungus, Aspergillus aculeatinus Tax-6, and its mutant strain.Scientific reports · 2020Article
- Chemical Profile and Biological Activities of Essential Oil fromPharmaceuticals (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Plant secondary metabolism evolved in the context of highly organized and differentiated cells and tissues, featuring massive chemical complexity operating under tight environmental, developmental and genetic control. Biotechnological demand for natural products has been continuously increasing because of their significant value and new applications, mainly as pharmaceuticals. Aseptic production systems of plant secondary metabolites have improved considerably, constituting an attractive tool for increased, stable and large-scale supply of valuable molecules. Surprisingly, to date, only a few examples including taxol, shikonin, berberine and artemisinin have emerged as success cases of commercial production using this strategy. The present review focuses on the main characteristics of plant specialized metabolism and their implications for current strategies used to produce secondary compounds in axenic cultivation systems. The search for consonance between plant secondary metabolism unique features and various in vitro culture systems, including cell, tissue, organ, and engineered cultures, as well as heterologous expression in microbial platforms, is discussed. Data to date strongly suggest that attaining full potential of these biotechnology production strategies requires being able to take advantage of plant specialized metabolism singularities for improved target molecule yields and for bypassing inherent difficulties in its rational manipulation.
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29290031What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.