Evidence map›Paper›PMID 29289934›Full record

ArticleBMJ open2017

Wait a minute? An observational cohort study comparing iron stores in healthy Swedish infants at 4 months of age after 10-, 60- and 180-second umbilical cord clamping.

Ulrica Askelöf, Ola Andersson, Magnus Domellöf, Anders Fasth, Boubou Hallberg, Lena Hellström-Westas, Karin Pettersson, Magnus Westgren, Ingela E Wiklund, Cecilia Götherström

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01245296 (Early Versus Delayed Cord Clamping at Term), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01245296 nacompletednot on this map

Early Versus Delayed Cord Clamping at Term: Outcomes in Swedish Infants

TypeinterventionalSponsorUppsala UniversityRan2008 to 2010Enrolled392ConditionsIron Deficiency, Neonatal HyperbilirubinemiaArmsTiming of clamping the umbilical cord
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ulrica AskelöfDepartment of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.
Ola AnderssonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-3972-0457
Magnus DomellöfDepartment of Clinical Sciences, Unit for Pediatrics, Umeå University, Umeå, Sweden.
Anders FasthThe Swedish National Umbilical Cord Blood Bank, Sahlgrenska University Hospital, Gothenburg, Sweden.
Boubou HallbergDepartment of Neonatology, CLINTEC, Karolinska Institutet and University Hospital, Stockholm, Sweden.
Lena Hellström-WestasDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Karin PetterssonDepartment of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.
Magnus WestgrenDepartment of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.
Ingela E WiklundDepartment of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden.
Cecilia GötherströmDepartment of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3782-0048
Sahlgrenska University Hospital · SEUppsala University · SEDanderyds sjukhus · SEKarolinska University Hospital · SEUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveUmbilical cord blood (UCB) is a valuable stem cell source used for transplantation. Immediate umbilical cord (UC) clamping is widely practised, but delayed UC clamping is increasingly advocated to reduce possible infant anaemia. The aim of this study was to investigate an intermediate UC clamping time point and to evaluate iron status at the age of 4 months in infants who had the UC clamped after 60 s and compare the results with immediate and late UC clamping.

designProspective observational study with two historical controls.

settingA university hospital in Stockholm, Sweden, and a county hospital in Halland, Sweden.

methodsIron status was assessed at 4 months in 200 prospectively recruited term infants whose UC was clamped 60 s after birth. The newborn baby was held below the uterine level for the first 30 s before placing the infant on the mother's abdomen for additional 30 s. The results were compared with data from a previously conducted randomised controlled trial including infants subjected to UC clamping at ≤10 s (n=200) or ≥180 s (n=200) after delivery.

resultsAfter adjustment for age differences at the time of follow-up, serum ferritin concentrations were 77, 103 and 114 µg/L in the 10, 60 and 180 s groups, respectively. The adjusted ferritin concentration was significantly higher in the 60 s group compared with the 10 s group (P=0.002), while the difference between the 60 and 180 s groups was not significant (P=0.29).

conclusionIn this study of healthy term infants, 60 s UC clamping with 30 s lowering of the baby below the uterine level resulted in higher serum ferritin concentrations at 4 months compared with 10 s UC clamping. The results suggest that delaying the UC clamping for 60 s reduces the risk for iron deficiency. TRIAL REGISTRATION NUMBER: NCT01245296.

Indexed as

ConstrictionDelivery, ObstetricInfant HealthAdultAnemia, Iron-DeficiencyFemaleFerritinsFetal BloodHumansInfantInfant, NewbornIronIron DeficienciesMaleParturitionPostpartum PeriodFerritinsIronfetal medicineiron deficiencypaediatricsumbilical cord clamping

Identifiers

PMID29289934
PMCPMC5778270
OpenAlexW2776852104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.