ArticleActa biomaterialia2018
Reducible disulfide poly(beta-amino ester) hydrogels for antioxidant delivery.
Article in Acta biomaterialia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Biodegradable polyethylene glycol-based poly(β-amino ester) hydrogel for curcumin delivery in wound treatment.RSC advances · 2026Article
- Designing drug delivery systems: the impact of structural order and disorder for optimized therapeutic outcomes.Nanomedicine (London, England) · 2026Review
- Multifunctional carboxymethyl cellulose-based hydrogels with zwitterionic and silver nanowire components for wound management.iScience · 2026Article
- Poly(beta-amino esters): applications in immunology.Chemical science · 2026Review
- Antibacterial and pH-sensitive methacrylate poly-L-Arginine/poly (β-amino ester) polymer for soft tissue engineering.Journal of materials science. Materials in medicine · 2023Article
- Applications of Stimuli-Responsive Hydrogels in Bone and Cartilage Regeneration.Pharmaceutics · 2023Review
- Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment.Advanced healthcare materials · 2022Review
- Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity.Bioactive materials · 2022Article
- Glycidate as a High-Strength Epoxy Adhesive Curable with Amine under Ambient Conditions.Polymers · 2022Article
- Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering.Bioengineering (Basel, Switzerland) · 2020Review
- Recent Developments in the Reduction of Oxidative Stress through Antioxidant Polymeric Formulations.Pharmaceutics · 2019Review
- Highly Thiolated Poly (Beta-Amino Ester) Nanoparticles for Acute Redox Applications.Gels (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Recently, biomaterials have been designed to contain redox-sensitive moieties, such as thiols and disulfides, to impart responsive degradation and/or controlled release. However, due to the high sensitivity of cellular redox-based systems which maintain free-radical homeostasis (e.g. glutathione/glutathione disulfide), if these biomaterials modify the cellular redox environment, they may inadvertently affect cellular compatibility and/or oxidative stress defenses. In this work, we hypothesize that the degradation products of a poly(β-amino ester) (PBAE) hydrogel formed with redox sensitive disulfide (cystamine) crosslinking could serve as a supplement to the environmental cellular antioxidant defenses. Upon introduction into a reducing environment, these disulfide-containing hydrogels cleave to present bound-thiol groups, yet remain in the bulk form at up to 66 mol% cystamine of the total amines. By controlling the molar fraction of cystamine, it was apparent that the thiol content varied human umbilical vein endothelial cell (HUVEC) viability IC STATEMENT OF SIGNIFICANCE: In this work, we demonstrate a unique property of disulfide containing degradable biomaterials. By changing the redox state of the degradation products (from oxidized to reduced), it is possible to increase the IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.