Evidence map›Paper›PMID 29289659›Full record

ArticleHormones and behavior2018

Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion.

Kathryn L G Russart, Danielle Huk, Randy J Nelson, Lawrence S Kirschner

Open access · greenAbstract read
In one paragraph

Article in Hormones and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kathryn L G RussartDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: kathryn.russart@osumc.edu.
Danielle HukDepartment of Cancer Biology and Genetics, Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
Randy J NelsonDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Lawrence S KirschnerDepartment of Cancer Biology and Genetics, Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
The Ohio State University · USThe Ohio State University Wexner Medical Center · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
TRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1986 to 2011
$28.1M
Selective Modulation of Thyroidal RadioiodineP01CA124570 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2008 to 2017
$23.4M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
Adverse Consequences of Light at Night for Cerebral IschemiaR01NS092388 · NINDS · WEST VIRGINIA UNIVERSITY · PI DEVRIES, ANNE COURTNEY, NELSON, RANDY J. · 2015 to 2019
$2.3M
PKA and follicular thyroid carcinogenesis: Roles of interacting pathwaysR01CA170249 · NCI · OHIO STATE UNIVERSITY · PI KIRSCHNER, LAWRENCE S · 2013 to 2017
$1.6M
Dim light at night alters pancreatic cell signaling and predisposes to pancreatic adenocarcinomaR21CA202745 · NCI · OHIO STATE UNIVERSITY · PI CHBEIR, SOUHAD · 2016 to 2017
$368k
NCI NIH HHS P01 CA124570NCI NIH HHS R01 CA170249NCI NIH HHS R21 CA202745NIDDK NIH HHS P30 DK020593NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637NINDS NIH HHS R01 NS092388
6 · The paper itself

Abstract

Alterations in circulating thyroid hormone concentrations are associated with several psychological and behavioral disorders. In humans, behavioral disorders such as anxiety, depression, and attention-deficit hyperactivity disorder can be associated with thyroid disease. The Tpo-Cre;Prkar1a

Indexed as

AggressionAnimalsAnxietyBehavior, AnimalCyclic AMP-Dependent Protein Kinase RIalpha SubunitGene DeletionGenotypeGuanine Nucleotide Exchange FactorsMaleMiceMice, Inbred C57BLMice, Inbred CBAMice, KnockoutOrgan SpecificitySignal TransductionThyroid GlandCyclic AMP-Dependent Protein Kinase RIalpha SubunitEpac protein, mouseGuanine Nucleotide Exchange FactorsPrkar1a protein, mouseAggressionBehavioral phenotypingEpac1HyperthyroidismPrkar1a

Identifiers

PMID29289659
PMCPMC5828986
OpenAlexW2782123028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.