ArticleThe American journal of the medical sciences2018
The Association Between Major Depressive Disorder and Outcomes in Older Veterans Hospitalized With Pneumonia.
Article in The American journal of the medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Respiratory disease in people with major depressive disorder: A systematic review and Meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Major depressive disorders increase the susceptibility to self-reported infections in two German cohort studies.Social psychiatry and psychiatric epidemiology · 2023Article
- Effects of miR-124-3p Silencing on Neuronal Damage in the Hippocampus of Depression Rats by Regulating STAT3 Gene.Computational and mathematical methods in medicine · 2022Article
- Association between mental illness and COVID-19 susceptibility and clinical outcomes in South Korea: a nationwide cohort study.The lancet. Psychiatry · 2020Article
- Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China.BMC psychiatry · 2020Article
- Can Daily Walking Alone Reduce Pneumonia-Related Mortality among Older People?Scientific reports · 2020Article
- Differences between diabetic and non-diabetic patients with community-acquired pneumonia in primary care in Spain.BMC infectious diseases · 2019Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder ("depression") has been identified as an independent risk factor for mortality for many comorbid conditions, including heart failure, cancer and stroke. Major depressive disorder has also been linked to immune suppression by generating a chronic inflammatory state. However, the association between major depression and pneumonia has not been examined. The aim of this study was to examine the association between depression and outcomes, including mortality and intensive care unit admission, in Veterans hospitalized with pneumonia. MATERIALS AND
methodsWe conducted a retrospective national study using administrative data of patients hospitalized at any Veterans Administration acute care hospital. We included patients ≥65 years old hospitalized with pneumonia from 2002-2012. Depressed patients were further analyzed based on whether they were receiving medications to treat depression. We used generalized linear mixed effect models to examine the association of depression with the outcomes of interest after controlling for potential confounders.
resultsPatients with depression had a significantly higher 90-day mortality (odds ratio 1.12, 95% confidence interval 1.07-1.17) compared to patients without depression. Patients with untreated depression had a significantly higher 30-day (1.11, 1.04-1.20) and 90-day (1.20, 1.13-1.28) mortality, as well as significantly higher intensive care unit admission rates (1.12, 1.03-1.21), compared to patients with treated depression.
conclusionFor older veterans hospitalized with pneumonia, a concurrent diagnosis of major depressive disorder, and especially untreated depression, was associated with higher mortality. This highlights that untreated major depressive disorder is an independent risk factor for mortality for patients with pneumonia.
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