ArticleThe Journal of the Acoustical Society of America2017
Dynamics of cochlear nonlinearity: Automatic gain control or instantaneous damping?
Article in The Journal of the Acoustical Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- The Elusive Cochlear Filter: Wave Origin of Cochlear Cross-Frequency Masking.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- A convolutional neural-network model of human cochlear mechanics and filter tuning for real-time applications.Nature machine intelligence · 2021Article
- The interplay of organ-of-Corti vibrational modes, not tectorial- membrane resonance, sets outer-hair-cell stereocilia phase to produce cochlear amplification.Hearing research · 2020Review
- Asymmetry and Microstructure of Temporal-Suppression Patterns in Basilar-Membrane Responses to Clicks: Relation to Tonal Suppression and Traveling-Wave Dispersion.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Constraints imposed by zero-crossing invariance on cochlear models with two mechanical degrees of freedom.The Journal of the Acoustical Society of America · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Measurements of basilar-membrane (BM) motion show that the compressive nonlinearity of cochlear mechanical responses is not an instantaneous phenomenon. For this reason, the cochlear amplifier has been thought to incorporate an automatic gain control (AGC) mechanism characterized by a finite reaction time. This paper studies the effect of instantaneous nonlinear damping on the responses of oscillatory systems. The principal results are that (i) instantaneous nonlinear damping produces a noninstantaneous gain control that differs markedly from typical AGC strategies; (ii) the kinetics of compressive nonlinearity implied by the finite reaction time of an AGC system appear inconsistent with the nonlinear dynamics measured on the gerbil basilar membrane; and (iii) conversely, those nonlinear dynamics can be reproduced using an harmonic oscillator with instantaneous nonlinear damping. Furthermore, existing cochlear models that include instantaneous gain-control mechanisms capture the principal kinetics of BM nonlinearity. Thus, an AGC system with finite reaction time appears neither necessary nor sufficient to explain nonlinear gain control in the cochlea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.