Evidence map›Paper›PMID 29288794›Full record

ReviewBiochimica et biophysica acta. Molecular basis of disease2018

Role of central neurotensin in regulating feeding: Implications for the development and treatment of body weight disorders.

Laura E Schroeder, Gina M Leinninger

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laura E SchroederDepartment of Physiology, Michigan State University, East Lansing, MI 48823, United States.
Gina M LeinningerDepartment of Physiology, Michigan State University, East Lansing, MI 48823, United States. Electronic address: leinning@msu.edu.
Michigan State University · US

Funding

Role of Lateral Hypothalamic Neurotensin Neurons in Energy BalanceR01DK103808 · NIDDK · MICHIGAN STATE UNIVERSITY · PI Gina Marie Leinninger · 2014 to 2026
$4.8M
NIDDK NIH HHS R01 DK103808
6 · The paper itself

Abstract

The peptide neurotensin (Nts) was discovered within the brain over 40years ago and is implicated in regulating analgesia, body temperature, blood pressure, locomotor activity and feeding. Recent evidence suggests, however, that these disparate processes may be controlled via specific populations of Nts neurons and receptors. The neuronal mediators of Nts anorectic action are now beginning to be understood, and, as such, modulating specific Nts pathways might be useful in treating feeding and body weight disorders. This review considers mechanisms through which Nts normally regulates feeding and how disruptions in Nts signaling might contribute to the disordered feeding and body weight of schizophrenia, Parkinson's disease, anorexia nervosa, and obesity. Defining how Nts specifically mediates feeding vs. other aspects of physiology will inform the design of therapeutics that modify body weight without disrupting other important Nts-mediated physiology.

Indexed as

Appetite RegulationAnimalsBody WeightBrainFeeding and Eating DisordersFeeding BehaviorHumansNeurotensinObesityOverweightNeurotensinAnorexiaDopamineEnergy balanceNeurotensin receptorObesity

Identifiers

PMID29288794
PMCPMC5803395
OpenAlexW2777827753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.