ArticleThe Journal of physiology2018
Skeletal muscle microvascular and interstitial PO2 from rest to contractions.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- Effects of acute selective cyclooxygenase-2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance.Experimental physiology · 2025Trial
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- Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy.Experimental physiology · 2026Article
- Oxygen delivery and consumption in aging skeletal muscle: Insights from an electric analogy model of POPhysiological reports · 2026Article
- The Role of Nitric Oxide in Regulating Microvascular Oxygen Pressure During Diaphragm Contraction in Rats.Advances in experimental medicine and biology · 2026Article
- KMicrovascular research · 2025Article
- Rest-to-work and work-to-rest transients of interstitial POPhysiological reports · 2025Article
- Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity.Aging cell · 2025Article
- Transcapillary POJournal of vascular research · 2025Article
- Relationship between muscle venous blood oxygenation and near-infrared spectroscopy: quantitative analysis of the Hb and Mb contributions.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Dynamics of POFrontiers in physiology · 2023Article
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence?American journal of physiology. Heart and circulatory physiology · 2022Article
- Effects of pulmonary hypertension on microcirculatory hemodynamics in rat skeletal muscle.Microvascular research · 2022Article
- Oxygen flux from capillary to mitochondria: integration of contemporary discoveries.European journal of applied physiology · 2022Review
- Dynamics of capillary blood flow responses to acute local changes in oxygen and carbon dioxide concentrations.Frontiers in physiology · 2022Article
- The effects of pulmonary hypertension on skeletal muscle oxygen pressures in contracting rat spinotrapezius muscle.Experimental physiology · 2021Article
- Energy metabolism design of the striated muscle cell.Physiological reviews · 2021Review
- Sexual dimorphism in vascular ATP-sensitive KThe Journal of physiology · 2021Article
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsOxygen pressure gradients across the microvascular walls are essential for oxygen diffusion from blood to tissue cells. At any given flux, the magnitude of these transmural gradients is proportional to the local resistance. The greatest resistance to oxygen transport into skeletal muscle is considered to reside in the short distance between red blood cells and myocytes. Although crucial to oxygen transport, little is known about transmural pressure gradients within skeletal muscle during contractions. We evaluated oxygen pressures within both the skeletal muscle microvascular and interstitial spaces to determine transmural gradients during the rest-contraction transient in anaesthetized rats. The significant transmural gradient observed at rest was sustained during submaximal muscle contractions. Our findings support that the blood-myocyte interface provides substantial resistance to oxygen diffusion at rest and during contractions and suggest that modulations in microvascular haemodynamics and red blood cell distribution constitute primary mechanisms driving increased transmural oxygen flux with contractions. ABSTRACT: Oxygen pressure (PO2) gradients across the blood-myocyte interface are required for diffusive O
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.