Evidence map›Paper›PMID 29288525›Full record

ArticleMolecular ecology resources2018

Multi-allelic exact tests for Hardy-Weinberg equilibrium that account for gender.

Jan Graffelman, Bruce S Weir

Abstract read
In one paragraph

Article in Molecular ecology resources, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  5. The transitivity of the Hardy-Weinberg law.Forensic science international. Genetics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jan GraffelmanDepartment of Statistics and Operations Research, Universitat Politècnica de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-3900-0780
Bruce S WeirDepartment of Biostatistics, University of Washington, Seattle, WA, USA.

Funding

Theoretical Population Genetics SupplementR01GM075091 · NIGMS · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2006 to 2020
$4.7M
NIGMS NIH HHS R01 GM075091
6 · The paper itself

Abstract

Statistical tests for Hardy-Weinberg equilibrium are important elementary tools in genetic data analysis. X-chromosomal variants have long been tested by applying autosomal test procedures to females only, and gender is usually not considered when testing autosomal variants for equilibrium. Recently, we proposed specific X-chromosomal exact test procedures for bi-allelic variants that include the hemizygous males, as well as autosomal tests that consider gender. In this study, we present the extension of the previous work for variants with multiple alleles. A full enumeration algorithm is used for the exact calculations of tri-allelic variants. For variants with many alternate alleles, we use a permutation test. Some empirical examples with data from the 1,000 genomes project are discussed.

Indexed as

Computer SimulationGene FrequencyGenetic VariationAlgorithmsChromosomes, Human, Pair 7Chromosomes, Human, XFemaleGenotypeHumansMaleModels, GeneticSex Factorsindelmicrosatellitepermutation testX chromosome

Identifiers

PMID29288525
PMCPMC5969302

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.