ArticleClinical oral investigations2018
Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats.
Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The Role of Astaxanthin as an Antioxidant and Anti-Inflammatory Agent in Human Health: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Bioregulatory periodontal medicine: could the molecular networks, inflammation and system biology modify the auto-regulatory capacity of the patients?Frontiers in physiology · 2026Pooled it
- Evaluation of the antimicrobial effect of cannabidiol (CBD) in a multispecies subgingival biofilm model.Journal of oral microbiology · 2026Article
- Constructing a nomogram model for patients with cervical spondylotic myelopathy.Scientific reports · 2025Article
- Lithium Chloride rescues Monensin-potentiated Wnt signaling inhibition in inflammatory bone loss in rats.Brazilian dental journal · 2025Article
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- Anti-Inflammatory Properties of Plants from Serbian Traditional Medicine.Life (Basel, Switzerland) · 2023Review
- Physicochemical Characterization, Biocompatibility, and Antibacterial Properties of CMC/PVA/Polymers · 2023Article
- Antimicrobial activity of Desplac® oral gel in the subgingival multispecies biofilm formation.Frontiers in microbiology · 2023Article
- Propolis, Aloe Vera, Green Tea, Cranberry, Calendula, Myrrha and Salvia Properties against Periodontal Microorganisms.Microorganisms · 2022Review
- Molecular docking study and antireabsorptive activity of a semi-synthetic coumarin derivative from Platymiscium floribundum in the ligature-induced periodontitis in rats: the involvement of heme oxygenase-1.Clinical oral investigations · 2022Article
- Effects of 3% binahong (F1000Research · 2021Article
- Effects of Calendula Officinalis and Hypericum Perforatum on Antioxidant, Anti-Inflammatory, and Histopathology Indices of Induced Periodontitis in Male Rats.Journal of dentistry (Shiraz, Iran) · 2020Article
- Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.PloS one · 2019Article
- Evaluation of Antimicrobial Efficacy and Osteogenic Potential of Titanium Coated with Hydrogel ofJournal of microscopy and ultrastructureArticle
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this work was to evaluate the anti-inflammatory and antiresorptive effects of Calendula officinalis (CLO) on alveolar bone loss (ABL) in rats. MATERIAL AND
methodsMale Wistar rats were subjected to ABL by ligature with nylon thread around the second upper left molar. The contralateral hemimaxillae were used as control. Rats received saline solution (SAL) or CLO (10, 30, or 90 mg/kg) 30 min before ligature and daily until the 11th day. The maxillae were removed and prepared for macroscopic, radiographic, micro-tomographic, histopathologic, histometric analysis, and immunohistochemical localization of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG). The gingival tissues were used to quantify the myeloperoxidase (MPO) activity, tumor necrosis factor-alpha (TNF-α), and interleukin-1β (IL-1β) concentrations by ELISA. Blood samples were collected for leukogram and to evaluate the bone-specific alkaline phosphatase (BALP) activity and serum levels of aspartate and alanine transaminases (AST/ALT).
resultsThe bone loss induced by 11 days of ligature induced bone loss, reduced levels of BALP, leukocyte infiltration, increased MPO activity, gingival concentrations of TNF-α and IL-1β, and RANKL while reduced OPG immunoexpressions in the periodontal tissue and leukocytosis. Of the CLO, 90 mg/kg reduced bone loss, neutrophilia, the levels of pro-inflammatory mediators, and RANKL expression, while it increased OPG immunopositive cells and BALP serum levels, when compared to SAL. CLO did not affect either kidney or liver function, indicated by serum AST/ALT levels.
conclusionThe present data suggests that CLO reduced inflammatory bone resorption in experimental periodontitis, which may be mediated by its anti-inflammatory properties and its effects on bone metabolism. CLINICAL RELEVANCE: CLO can be a potential therapeutical adjuvant in the treatment of periodontitis.
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