ReviewJournal of exposure science & environmental epidemiology2018
Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA.
Review in Journal of exposure science & environmental epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Organizing mechanism-related information on chemical interactions using a framework based on the aggregate exposure and adverse outcome pathways.Environment international · 2020Pooled it
- Quantitative method comparison in non-targeted analysis using cascade classification.Analytical and bioanalytical chemistry · 2026Article
- Identifying Chemicals of Health Concern in Hair Extensions Using Suspect Screening and Nontargeted Analysis.Environment & health (Washington, D.C.) · 2026Article
- Non-Targeted Analysis of Carbofuran and Related Compounds in Commercial Formulations and Animal Tissue.Molecules (Basel, Switzerland) · 2026Article
- Prioritizing Chemical Candidates from Non-targeted Analysis Using Metadata, Spectral Similarity, and Hazard Scoring within INTERPRET NTA.Analytical chemistry · 2025Article
- The ENTAiLS Toolkit: an integrated workflow to perform non-targeted analysis of per- and polyfluoroalkyl substances.Analytical and bioanalytical chemistry · 2025Article
- Examining the effects of analytical replication on data quality in a non-targeted analysis experiment.Analytical and bioanalytical chemistry · 2025Article
- Household-Level Variability of Nontarget Analytical Results for Drinking Water Provides a Tool for Uncovering Constituents Introduced by Distribution System Components.Environmental science & technology · 2025Article
- Prioritization of Unknown LC-HRMS Features Based on Predicted Toxicity Categories.Environmental science & technology · 2025Article
- Perfluorinated carbon chain length drives uptake of diverse Per- and polyfluoroalkyl substances in field-deployed passive samplers.ACS ES&T water · 2025Article
- Automated QA/QC reporting for non-targeted analysis: a demonstration of "INTERPRET NTA" with de facto water reuse data.Analytical and bioanalytical chemistry · 2025Article
- Environmental Applications of Mass Spectrometry for Emerging Contaminants.Molecules (Basel, Switzerland) · 2025Review
- Review
- Quantitative Non-targeted Screening to Profile Micropollutants in Sewage Sludge Used for Agricultural Field Amendments.Environmental science & technology · 2024Article
- Improving predictions of compound amenability for liquid chromatography-mass spectrometry to enhance non-targeted analysis.Analytical and bioanalytical chemistry · 2024Article
- Free and open-source QSAR-ready workflow for automated standardization of chemical structures in support of QSAR modeling.Journal of cheminformatics · 2024Article
- Quantification of chemicals in non-targeted analysis without analytical standards - Understanding the mechanism of electrospray ionization and making predictions.Current opinion in environmental science & health · 2024Article
- Suspect Screening Analysis of Pooled Human Serum Samples Using GC × GC/TOF-MS.Environmental science & technology · 2024Article
- Screening for drinking water contaminants of concern using an automated exposure-focused workflow.Journal of exposure science & environmental epidemiology · 2024Article
- Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data.Environmental health perspectives · 2024Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Tens-of-thousands of chemicals are registered in the U.S. for use in countless processes and products. Recent evidence suggests that many of these chemicals are measureable in environmental and/or biological systems, indicating the potential for widespread exposures. Traditional public health research tools, including in vivo studies and targeted analytical chemistry methods, have been unable to meet the needs of screening programs designed to evaluate chemical safety. As such, new tools have been developed to enable rapid assessment of potentially harmful chemical exposures and their attendant biological responses. One group of tools, known as "non-targeted analysis" (NTA) methods, allows the rapid characterization of thousands of never-before-studied compounds in a wide variety of environmental, residential, and biological media. This article discusses current applications of NTA methods, challenges to their effective use in chemical screening studies, and ways in which shared resources (e.g., chemical standards, databases, model predictions, and media measurements) can advance their use in risk-based chemical prioritization. A brief review is provided of resources and projects within EPA's Office of Research and Development (ORD) that provide benefit to, and receive benefits from, NTA research endeavors. A summary of EPA's Non-Targeted Analysis Collaborative Trial (ENTACT) is also given, which makes direct use of ORD resources to benefit the global NTA research community. Finally, a research framework is described that shows how NTA methods will bridge chemical prioritization efforts within ORD. This framework exists as a guide for institutions seeking to understand the complexity of chemical exposures, and the impact of these exposures on living systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.