SynthesisJournal of the American Academy of Dermatology2018
Dermatologic manifestations of solid organ transplantation-associated graft-versus-host disease: A systematic review.
Synthesis in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Effective treatment of acute graft-versus-host disease following liver transplantation using an integrated regimen centered on antithymocyte globulin: a single-center experience.Frontiers in immunology · 2026Article
- Dermatologic manifestations of acute graft versus host disease after liver transplantation: A case series of 8 patients.JAAD case reports · 2023Article
- Solid organ graft-versus-host disease in a recipient of a COVID-19 positive liver graft.Journal of liver transplantation · 2023Article
- HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation.Nature communications · 2022Article
- Diagnostic and therapeutic dilemma in Stevens-Johnson syndrome-like acute graft-versus-host disease after liver transplantation: A case report.Frontiers in immunology · 2022Article
- Graft versus host disease after liver transplantation following radiotherapy for the treatment of hepatocellular carcinoma: A case report and literature review.SAGE open medical case reports · 2022Article
- Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: Report of six cases.World journal of clinical cases · 2021Article
- Graft-versus-host disease after simultaneous pancreas-kidney transplantation.Korean journal of transplantation · 2020Article
- Common and critical inflammatory dermatoses every pathologist should know.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Review
- Graft-Versus-Host Disease After Pancreatic Transplantation.ACG case reports journal · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGraft-versus-host-disease (GVHD) after solid organ transplantation (SOT) is extremely rare.
objectiveTo investigate the dermatologic manifestations and clinical outcomes of SOT GVHD.
methodsSystematic literature review of SOT GVHD.
resultsAfter full-text article review, we included 61 articles, representing 115 patients and 126 transplanted organs. The most commonly transplanted organ was the liver (n = 81). Among 115 patients, 101 (87.8%) developed skin involvement. The eruption appeared an average of 48.3 days (range, 3-243 days) posttransplant and was pruritic in 5 of 101 (4.9%) cases. The eruption was described as morbilliform in 2 patients (1.9%), confluent in 6 (5.9%), and desquamative in 4 (3.9%) cases. In many cases, specific dermatologic descriptions were lacking. The mortality rate was 72.2%. Relative time of death was reported in 23 patients who died during the follow-up period. These patients died an average of 99.2 days (range, 22-270 days) posttransplant, or 50.9 days after the appearance of dermatologic symptoms. Frequent causes of death were sepsis and multiorgan failure. LIMITATIONS: Incomplete descriptions of skin findings and potential publication bias resulting in publication of only the most severe cases.
conclusionsGVHD is a potentially fatal condition that can occur after SOT and often presents with a skin rash. We recommend that dermatologists have a low threshold to consider and pursue this diagnosis in the setting of post-SOT skin eruption.
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