ReviewInternational journal of cardiology2018
The role of DNA methylation in the association between childhood adversity and cardiometabolic disease.
Review in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Is virtue its own reward? Moral identity, empathy, and volunteering during adolescence as predictors of subsequent epigenetic aging.Applied psychology. Health and well-being · 2025Article
- Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing.PLoS genetics · 2025Article
- Adolescent empathy and epigenetic aging in adulthood: Substance use as a mediator.Developmental psychology · 2025Article
- Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor.Brain, behavior, and immunity · 2024Article
- Cumulative Stress Across the Life Course and Biological Aging in Adulthood.Psychosomatic medicine · 2024Article
- Neighborhood Disadvantage and Parenting in Early Adolescence Predict Epigenetic Aging and Mortality Risk in Adulthood.Journal of youth and adolescence · 2024Article
- Article
- Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.Nutrients · 2023Article
- Childhood Neighborhood Disadvantage, Parenting, and Adult Health.American journal of preventive medicine · 2022Article
- Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage.Current medical science · 2022Review
- Interpersonal Trauma and Risk of Incident Cardiovascular Disease Events Among Women.Journal of the American Heart Association · 2022Article
- How to Mitigate Risk of Premature Cardiovascular Disease Among Children and Adolescents with Mental Health Conditions.Current atherosclerosis reports · 2022Review
- Timing, duration, and differential susceptibility to early life adversities and cardiovascular disease risk across the lifespan: Implications for future research.Preventive medicine · 2021Review
- Statistical methods for mediation analysis in the era of high-throughput genomics: Current successes and future challenges.Computational and structural biotechnology journal · 2021Review
- Shared Physiologic Pathways Among Comorbidities for Adults With Cerebral Palsy.Frontiers in neurology · 2021Article
- Social Determinants of Cardiovascular Health: Early Life Adversity as a Contributor to Disparities in Cardiovascular Diseases.The Journal of pediatrics · 2020Article
- Racial differences in skeletal fragility but not osteoarthritis among women and men with cerebral palsy.Bone reports · 2019Article
- DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure.Clinical epigenetics · 2019Article
- Infant Psychosocial Environment Predicts Adolescent Cardiometabolic Risk: A Prospective Study.The Journal of pediatrics · 2019Article
- Epigenetic machine learning: utilizing DNA methylation patterns to predict spastic cerebral palsy.BMC bioinformatics · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Growing evidence suggests that adverse environmental stimuli, especially during sensitive periods in early life, may lead to cardiometabolic disease in later life. However, the underlying biological mechanisms remain a mystery. Recent studies inferred that epigenetic modifications are likely involved. We review recent studies, primarily focused on the findings from human studies, to indicate the role of DNA methylation in the associations between childhood adversity and cardiometabolic disease in adulthood. In particular, we focused on DNA methylation modifications in genes regulating the hypothalamus-pituitary-adrenal axis as well as the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.