Evidence map›Paper›PMID 29287999›Full record

ArticleUltrasound in medicine & biology2018

The Dependence of Glomerular Capillary Hemorrhage Induced by Contrast Enhanced Diagnostic Ultrasound on Microbubble Diameter.

Douglas L Miller, Xiaofang Lu, Chunyan Dou, Mario L Fabiilli, Charles C Church

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Douglas L MillerDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA. Electronic address: douglm@umich.edu.
Xiaofang LuDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Chunyan DouDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Mario L FabiilliDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Charles C ChurchNational Center for Physical Acoustics, University of Mississippi, University, Mississippi, USA; Department of Physics and Astronomy, University of Mississippi, University, Mississippi, USA.
Michigan Medicine · USUniversity of Mississippi · US

Funding

Dosimetry of Cavitation Microlesions in Microbubble Enhanced Medical UltrasoundR01HL110990 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, DOUGLAS LAWRENCE · 2013 to 2016
$1.7M
NHLBI NIH HHS R01 HL110990
6 · The paper itself

Abstract

A recently proposed two-criterion model for cavitational bioeffects in tissue with microbubbles (MBs) was tested. The glomerular capillary hemorrhage bioeffect was observed in rat kidney for contrast agent MB suspensions with mean diameters of 1.6, 3.1 and 5.5 µm. A diagnostic ultrasound machine was used at 3.6 MHz and 5.5 MHz for intermittent scans at power settings 2 dB apart. Petechial hemorrhage counts scored on the surface of the kidneys, and glomeruli were scored in histology. Thresholds for the petechial hemorrhage measurements were the same for the large and medium MB suspensions but substantially higher for the small MBs. For the histology, the medium MBs gave a higher threshold than the large MBs at 5.5 MHz. The pressure amplitude thresholds are in approximate agreement with theory, and the optimum MB size counterintuitively increased for increasing ultrasound frequency, as predicted. The two-criterion model of MB-associated capillary hemorrhage is supported.

Indexed as

AnimalsCapillariesContrast MediaDisease Models, AnimalHemorrhageImage EnhancementKidneyMicrobubblesRatsUltrasonographyContrast MediaContrast enhanced diagnostic ultrasoundContrast microbubblesMechanical indexTheoretical microbubble dynamicsUltrasonic cavitational bioeffects

Identifiers

PMID29287999
PMCPMC5800985
OpenAlexW2779005635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.