Evidence map›Paper›PMID 29287983›Full record

ArticleMicrobes and infection2018

Inducible nitric oxide synthase in innate immune cells is important for restricting cyst formation of Toxoplasma gondii in the brain but not required for the protective immune process to remove the cysts.

Qila Sa, Ashish Tiwari, Eri Ochiai, Jeremi Mullins, Yasuhiro Suzuki

Open access · bronzeAbstract read
In one paragraph

Article in Microbes and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Nitric oxide in parasitic infections: a friend or foe?Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Penetration of CD8The American journal of pathology · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qila SaDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Ashish TiwariDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Eri OchiaiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Jeremi MullinsDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Yasuhiro SuzukiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: yasu.suzuki@uky.edu.
University of Kentucky · US

Funding

Cooperation of CD8+ T cells and phagocytes to eliminate Toxoplasma cystsR01AI095032 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2012 to 2023
$4.1M
IFN-gamma production by microglia for prevention of toxoplasmic encephalitisR01AI078756 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SUZUKI, YASUHIRO · 2008 to 2012
$1.8M
NIAID NIH HHS R01 AI078756NIAID NIH HHS R01 AI095032
6 · The paper itself

Abstract

Significantly larger numbers of Toxoplasma gondii cysts were detected in the brains of RAG1

Indexed as

Immunity, InnateAnimalsBrainCD8-Positive T-LymphocytesChloroquineFemaleMiceMice, Inbred BALB CMice, SCIDNitric Oxide Synthase Type IIPhagosomesToxoplasmaToxoplasmosis, AnimalChloroquineNitric Oxide Synthase Type IINos2 protein, mouseCD8(+) T cellsCystInducible nitric oxide synthasePhagolysosomeToxoplasma gondii

Identifiers

PMID29287983
PMCPMC5911423
OpenAlexW2779065254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.