Evidence map›Paper›PMID 29287907›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2018

NIR-induced spatiotemporally controlled gene silencing by upconversion nanoparticle-based siRNA nanocarrier.

Guojun Chen, Ben Ma, Ruosen Xie, Yuyuan Wang, Kefeng Dou, Shaoqin Gong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Guojun ChenDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA; Wisconsin Institute for Discovery, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA.
Ben MaWisconsin Institute for Discovery, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China.
Ruosen XieDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA; Wisconsin Institute for Discovery, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA.
Yuyuan WangDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA; Wisconsin Institute for Discovery, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA.
Kefeng DouDepartment of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China. Electronic address: doukef@fmmu.edu.cn.
Shaoqin GongDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA; Wisconsin Institute for Discovery, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53715, USA. Electronic address: shaoqingong@wisc.edu.
University of Wisconsin–Madison · USWisconsin Institutes for Discovery · USXijing Hospital · CN

Funding

Targeted Therapy of Neuroendocrine Cancers Via the Notch Signaling PathwayK25CA166178 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GONG, SHAOQIN - · 2013 to 2017
$994k
Targeting Triple Negative Breast Cancer Using Nanoparticles Loaded with the Anti-Cancer Drug AminoflavoneR21CA196653 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GONG, SHAOQIN -, XU, WEI · 2016 to 2017
$337k
NCI NIH HHS K25 CA166178NCI NIH HHS R21 CA196653
6 · The paper itself

Abstract

Spatiotemporal control over the release or activation of biomacromolecules such as siRNA remains a significant challenge. Light-controlled release has gained popularity in recent years; however, a major limitation is that most photoactivable compounds/systems respond only to UV irradiation, but not near-infrared (NIR) light that offers a deeper tissue penetration depth and better biocompatibility. This paper reports a simple NIR-to-UV upconversion nanoparticle (UCNP)-based siRNA nanocarrier for NIR-controlled gene silencing. siRNA is complexed onto a NaYF

Indexed as

RNA InterferenceAzo CompoundsCell Line, TumorCyclodextrinsDelayed-Action PreparationsFluoridesGreen Fluorescent ProteinsHumansInfrared RaysNanoparticlesRNA, Small InterferingYttriumazobenzeneAzo CompoundsCyclodextrinsDelayed-Action PreparationsFluoridesGreen Fluorescent ProteinsRNA, Small Interferingsodium yttriumtetrafluorideYttriumHost–guest interactionNIR-controlled releaseSpatiotemporally controlled gene silencingUpconversion nanoparticle

Identifiers

PMID29287907
PMCPMC6008219
OpenAlexW2779714997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.