ArticleContemporary clinical trials2018
Tobacco dependence treatment in the emergency department: A randomized trial using the Multiphase Optimization Strategy.
Article in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Tobacco Dependence Treatment in the Emergency Department
Physical Activity in Adolescents With Chronic Kidney Disease
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Telephone counselling for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Evidence-based brief cessation advice plus active referral for emergency department patients who smoke: a single-arm, real-world clinical trial.BMC medicine · 2025Trial
- Successful Optimization of Tobacco Dependence Treatment in the Emergency Department: A Randomized Controlled Trial Using the Multiphase Optimization Strategy.Annals of emergency medicine · 2023Trial
- Advances in clinical trials methodology: Intervention optimization approaches in emergency medicine.The American journal of emergency medicine · 2022Trial
- A Hybrid Evaluation-Optimization Trial to Evaluate an Intervention Targeting the Intersection of Alcohol and Sex in College Students and Simultaneously Test an Additional Component Aimed at Preventing Sexual Violence.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021Trial
- Effectiveness of a Dyadic Buddy App for Smoking Cessation: Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Optimizing diabetes management interventions for Black and Hispanic adults using the multiphase optimization strategy: Protocol for a randomized mixed methods factorial trial.Contemporary clinical trials · 2025Article
- Optimization of implementation strategies using the Multiphase Optimization STratgey (MOST) framework: Practical guidance using the factorial design.Translational behavioral medicine · 2024Article
- Optimizing the physical activity intervention for older adults with mild cognitive impairment: a factorial randomized trial.Frontiers in sports and active living · 2024Article
- Optimising engagement in a digital parenting intervention to prevent violence against adolescents in Tanzania: protocol for a cluster randomised factorial trial.BMC public health · 2023Article
- Optimizing intervention components for sleep promotion in children in the context of obesity prevention: the SLEEPY 2.0 study protocol.Frontiers in sleep · 2023Article
- Pragmatic clinical trial design in emergency medicine: Study considerations and design types.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022Article
- Using factorial mediation analysis to better understand the effects of interventions.Translational behavioral medicine · 2022Article
- One view of the next decade of research on behavioral and biobehavioral approaches to cancer prevention and control: intervention optimization.Translational behavioral medicine · 2021Review
- Optimizing the Context of Support to Improve Outcomes of Internet-Based Self-help in Individuals With Depressive Symptoms: Protocol for a Randomized Factorial Trial.JMIR research protocols · 2021Article
- Who are we missing with EHR-Based Smoking Cessation Treatments? A Descriptive Study of Patients who Smoke and Do Not Regularly Visit Primary Care Clinics.Journal of smoking cessation · 2020Article
- Article
- Simulation and minimization: technical advances for factorial experiments designed to optimize clinical interventions.BMC medical research methodology · 2019Article
- Mobile phone text messaging and app-based interventions for smoking cessation.The Cochrane database of systematic reviews · 2019Review
- Motivational interviewing for smoking cessation.The Cochrane database of systematic reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundTobacco dependence remains the leading preventable cause of death in the developed world. Smokers are disproportionately from lower socioeconomic groups, and may use the hospital emergency department (ED) as an important source of care. A recent clinical trial demonstrated the efficacy of a multicomponent intervention to help smokers quit, but the independent contributions of those components is unknown.
methodsThis is a full-factorial (16-arm) randomized trial in a busy hospital ED of 4 tobacco dependence interventions: brief motivational interviewing, nicotine replacement therapy, referral to a telephone quitline, and a texting program. The trial utilizes the Multiphase Optimization Strategy (MOST) and a novel mixed methods analytic design to assess clinical efficacy, cost effectiveness, and qualitative participant feedback. The primary endpoint is tobacco abstinence at 3months, verified by participants' exhaled carbon monoxide.
resultsStudy enrollment began in February 2017. As of April 2017, 52 of 1056 planned participants (4.9%) were enrolled. Telephone-based semi-structured participant interviews and in-person biochemical verification of smoking abstinence are completed at the 3-month follow-up. Efficacy and cost effectiveness analyses will be conducted after follow-up is completed. DISCUSSION: The goal of this study is to identify a clinically efficacious, cost-effective intervention package for the initial treatment of tobacco dependence in ED patients. The efficacy of this combination can then be tested in a subsequent confirmatory trial. Our approach incorporates qualitative feedback from study participants in evaluating which intervention components will be tested in the future trial.
trial registrationTrial (NCT02896400) registered in ClinicalTrials.gov on September 6, 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.