ArticleContemporary clinical trials2018
A sequential multiple assignment randomized trial for cocaine cessation and relapse prevention: Tailoring treatment to the individual.
Article in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sequential multiple assignment randomized trial studies should report all key components: a systematic review.Journal of clinical epidemiology · 2022Pooled it
- Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: Outcomes from a sequential multiple assignment randomized controlled trial.Drug and alcohol dependence · 2025Trial
- Undervaluing nondrug rewards or overvaluing cocaine? Cocaine demand relates to cocaine use severity more strongly than anhedonia in individuals with cocaine use disorder.Experimental and clinical psychopharmacology · 2025Trial
- Web-based interpretation bias training to reduce anxiety: A sequential, multiple-assignment randomized trial.Journal of consulting and clinical psychology · 2024Trial
- Treating intrusive memories after trauma in healthcare workers: a Bayesian adaptive randomised trial developing an imagery-competing task intervention.Molecular psychiatry · 2023Trial
- Optimal allocation to treatments in a sequential multiple assignment randomized trial.Statistical methods in medical research · 2021Trial
- Repurposing semaglutide as an adjunctive treatment for cocaine use disorder: protocol for a randomised controlled trial.BMJ open · 2026Article
- Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand.Experimental and clinical psychopharmacology · 2023Article
- Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: A sequential multiple assignment randomized controlled trial protocol.Contemporary clinical trials · 2023Article
- Optimizing adaptive stepped-care interventions to change adults' health behaviors: A systematic review.Journal of clinical and translational science · 2023Review
- Joint modeling and multiple comparisons with the best of data from a SMART with survival outcomes.Biostatistics (Oxford, England) · 2022Article
- Lost in Translation: the Gap Between Neurobiological Mechanisms and Psychosocial Treatment Research for Substance Use Disorders.Current addiction reports · 2021Article
- An adaptive clinical trial design for cocaine use disorder: Extended-release amphetamine salts for early behavioral intervention non-responders.Contemporary clinical trials · 2020Article
- Baseline cocaine demand predicts contingency management treatment outcomes for cocaine-use disorder.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Drug addiction is a chronic, devastating, but treatable disorder. A core principle of drug addiction treatment states that no single treatment is appropriate for everyone (NIDA, 2012); treatments need to adjust based on patient characteristics and response in order to be maximally effective. For cocaine use disorders (CUD), specifically, the most potent intervention currently available for initiating abstinence is behavior therapy using contingency management (CM) procedures, with early cessation being a robust predictor of future abstinence. This raises two key questions for treatment development research: First, can we significantly improve initial CM response rates with targeted adjunctive interventions? Second, for individuals who fail to achieve initial abstinence with CM, is pharmacotherapy an effective augmentation strategy? This paper describes how a sequential, multiple assignment, randomized trial (SMART) design has advantages over a fixed-intervention approach when it comes to collecting data needed to answer both questions. The first aim will examine whether Acceptance and Commitment Therapy (ACT) in combination with CM increases initial abstinence response rates (i.e., 2 consecutive weeks of cocaine-negative urine screens). The second aim will examine whether ACT+CM in combination with modafinil promotes abstinence achievement in initial non-responders. Results are expected to inform how we tailor treatment of CUD to maximize outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.