Evidence map›Paper›PMID 29287628›Full record

ReviewNeuroscience and biobehavioral reviews2018

Sex differences in the brain: Implications for behavioral and biomedical research.

Elena Choleris, Liisa A M Galea, Farida Sohrabji, Karyn M Frick

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 221 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Neuron-specific epigenetic repression ofbioRxiv : the preprint server for biology · 2026
    Article
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  7. Article
  8. Article
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  10. Derepression of transposable elements in the mouse prefrontal cortex disrupts social behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Evidence for an Evolutionary Continuity in Social Dominance: Insights from Nonhuman Primate Tractography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Effects of TBBPA Exposure on Neurodevelopment and Behavior in Mice.International journal of molecular sciences · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Elena CholerisDepartment of Psychology and Neuroscience Program, University of Guelph, MacKinnon Bldg. Room 4020, Guelph, ON N1G 2W1, Canada. Electronic address: echoleri@uoguelph.ca.
Liisa A M GaleaDepartment of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
Farida SohrabjiWomen's Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A&M HSC College of Medicine, Bryan, TX 77807, United States.
Karyn M FrickDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States.
Texas A&M Health Science Center · USUniversity of British Columbia · CAUniversity of Guelph · CAUniversity of Wisconsin–Milwaukee · US

Funding

Epigenetics of the Aging Astrocyte: Implications for StrokeR01AG042189 · NIA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Farida Sohrabji · 2011 to 2026
$3.1M
Epigenetics of the Aging Astrocyte: Implications for StrokeRF1AG042189 · NIA · TEXAS A&M UNIVERSITY · PI SOHRABJI, FARIDA · 2018 to 2018
$2.8M
Mechanisms underlying memory regulation by 17beta-estradiol, canonical Wnt signaling, and BDNF in male and female miceR01MH107886 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI FRICK, KARYN M · 2016 to 2020
$1.9M
Neuroprotection in the Aging Female BrainR01NS074895 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SOHRABJI, FARIDA · 2011 to 2015
$1.7M
Hormone and enrichment effects on memory in aging miceR01AG022525 · NIA · YALE UNIVERSITY · PI FRICK, KARYN M · 2005 to 2009
$1.3M
Neuroprotection in the aging female brainR56NS074895 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SOHRABJI, FARIDA · 2017 to 2017
$520k
Estrogenic-cholinergic interactions in memory modulationR03MH065460 · NIMH · YALE UNIVERSITY · PI FRICK, KARYN M · 2003 to 2004
$156k
NIA NIH HHS R01 AG022525NIA NIH HHS R01 AG042189NIA NIH HHS RF1 AG042189NIMH NIH HHS R01 MH107886NIMH NIH HHS R03 MH065460NINDS NIH HHS R01 NS074895NINDS NIH HHS R56 NS074895
6 · The paper itself

Abstract

Biological differences between males and females are found at multiple levels. However, females have too often been under-represented in behavioral neuroscience research, which has stymied the study of potential sex differences in neurobiology and behavior. This review focuses on the study of sex differences in the neurobiology of social behavior, memory, emotions, and recovery from brain injury, with particular emphasis on the role of estrogens in regulating forebrain function. This work, presented by the authors at the 2016 meeting of the International Behavioral Neuroscience Society, emphasizes varying approaches from several mammalian species in which sex differences have not only been documented, but also become the focus of efforts to understand the mechanistic basis underlying them. This information may provide readers with useful experimental tools to successfully address recently introduced regulations by granting agencies that either require (e.g. the National Institutes of Health in the United States and the Canadian Institutes of Health Research in Canada) or recommend (e.g. Horizon 2020 in Europe) the inclusion of both sexes in biomedical research.

Indexed as

Sex CharacteristicsSocial BehaviorAnimalsBrainEmotionsEstrogensHumansMemoryEstrogensCell deathCerebral ischemiaEpigeneticsEstradiolHippocampusMemoryNeurogenesisPattern separationSocial behaviorStroke

Identifiers

PMID29287628
PMCPMC5751942
OpenAlexW2781127606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.