Evidence map›Paper›PMID 29287229›Full record

ArticleVirology2018

Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice.

Charlie C Hsu, Stacey M Meeker, Sabine Escobar, Thea L Brabb, Jisun Paik, Heon Park, Brian M Iritani, Lillian Maggio-Price

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Charlie C HsuDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
Stacey M MeekerDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
Sabine EscobarDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
Thea L BrabbDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
Jisun PaikDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
Heon ParkDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
Brian M IritaniDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
Lillian Maggio-PriceDepartment of Comparative Medicine, University of Washington, Seattle, WA, United States.
University of Washington · US

Funding

Targeting Fnip1 to disrupt B cell development, metabolism, and transformationR01AI114556 · NIAID · UNIVERSITY OF WASHINGTON · PI IRITANI, BRIAN M · 2015 to 2019
$2.0M
MNV-4, an Emerging Pathogen in Murine Models of Inflammatory Bowel DiseaseR01OD011149 · OD · UNIVERSITY OF WASHINGTON · PI MAGGIO-PRICE, LILLIAN · 2012 to 2015
$1.5M
Vitamin D mediated protection in inflammatory bowel diseaseK01OD021420 · OD · UNIVERSITY OF WASHINGTON · PI MEEKER, STACEY MARIE · 2016 to 2019
$592k
Folliculin Interacting Proteins in Lymphocyte Development and AutoimmunityR21AI109020 · NIAID · UNIVERSITY OF WASHINGTON · PI IRITANI, BRIAN M · 2014 to 2015
$425k
ANTIBODY CATALYZED POLYMERIZATION AND GLYCOSYLATIONF32AI009093 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANAGAN, MARK E · 1994 to 1996
–
NIAID NIH HHS F32 AI009093NIAID NIH HHS R01 AI114556NIAID NIH HHS R21 AI109020NIH HHS K01 OD021420NIH HHS R01 OD011149
6 · The paper itself

Abstract

Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1

Indexed as

AnimalsB-LymphocytesBone MarrowCaliciviridae InfectionsFemaleGastroenteritisHumansMaleMiceMice, Inbred C57BLMice, KnockoutNorovirusSTAT1 Transcription FactorVirus ReplicationStat1 protein, mouseSTAT1 Transcription FactorB cellsB lymphocytesCalicivirusMurine norovirusNorovirusStat1

Identifiers

PMID29287229
PMCPMC5801037
OpenAlexW2781138490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.