ArticlePloS one2017
Metastatic spinal cord compression (MSCC) treated with palliative decompression: Surgical timing and survival rate.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Systematic Review and Meta-Analysis on Optimal Timing of Surgery for Acute Symptomatic Metastatic Spinal Cord Compression.Medicina (Kaunas, Lithuania) · 2024Pooled it
- The role of surgical timing in survival of patients with spinal metastases.International journal of clinical oncology · 2026Article
- A stable and potent buffalo EF1α1 promoter for robust gene expression in mammalian systems.Transgenic research · 2026Article
- Exploring clinical and demographic determinants of time to treatment in spinal metastases: A Large-Scale cohort study of more than 1000 patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Survival after spinal surgery for metastases in men with castration-sensitive vs castration-resistant prostate cancer: a nationwide register-based study.Scientific reports · 2026Article
- Timing and neurological recovery in metastatic spinal cord compression: short and long-term outcomes of the internal bracing technique.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- The Spinal Instability Neoplastic Score correlates with epidural spinal cord compression -a retrospective cohort of 256 surgically treated patients with spinal metastases.BMC musculoskeletal disorders · 2024Article
- Valuation of EQ-5D-5L health states from cancer patients' perspective: a feasibility study.The European journal of health economics : HEPAC : health economics in prevention and care · 2024Article
- Enhancing the referral process for surgical management of spinal metastases: insights from a 12-year, bi-institutional study of 533 patients.Frontiers in oncology · 2024Article
- Determining patients with spinal metastases suitable for surgical intervention: A cost-effective analysis.Cancer medicine · 2023Article
- Time to Surgical Treatment for Metastatic Spinal Disease: Identification of Delay Intervals.Global spine journal · 2023Article
- Article
- A systematic review of MIS and open decompression surgery for spinal metastases in the last two decades.Journal of clinical orthopaedics and trauma · 2021Review
- Preoperative Embolization of Spinal Metastatic Tumor: The Use of Selective Computed Tomography Angiography for the Detection of Radiculomedullary Arteries.Spine surgery and related research · 2021Article
- Patient experiences of decision-making in the treatment of spinal metastases: a qualitative study.The spine journal : official journal of the North American Spine Society · 2020Article
- Non-operative management of spinal metastases: A prognostic model for failure.Clinical neurology and neurosurgery · 2020Article
- Article
- Prognosticating outcomes and survival for patients with lumbar spinal metastases: Results of a bayesian regression analysis.Clinical neurology and neurosurgery · 2019Article
- Top Ten Tips Palliative Care Clinicians Should Know About Spinal Tumors.Journal of palliative medicine · 2019Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastatic spinal cord compression (MSCC) treatment depends on life expectancies. Data regarding palliative decompression outcomes is scarce. We demonstrate that surgical timing has a significant impact on survival in MSCC patients treated with palliative decompression.
methodsEighty-nine consecutive MSCC patients at a tertiary referral medical center were enrolled between January 2012 and February 2016. Wide laminectomy was performed for tumors invading the vertebral body. Debulking surgery was done for tumors damaging the posterior column of the spine. Patient records were retrospectively analyzed.
resultsBetter survival was observed in patients with preoperative intact motor function (Group A, n = 37) than in those with motor deficit (Group B, n = 52, p = 0.0031). In Group B, survival was better in those who underwent surgery within 7 days of motor deficit onset than in those who underwent surgery 7 days after onset (p = 0.0444) and in postoperative ambulant patients than in nonambulant patients (p = 0.0120). In Group B, Frankel grade improved in patients who underwent surgery within 48 h than in those who underwent surgery after 48 h (p = 0.0992). Group A patients had a shorter hospital stay and higher revised Tokuhashi score than Group B patients. Overall survival was better in patients with a lower Tomita score (≤5, p = 0.0012), higher revised Tokuhashi score (≥9, p = 0.0009), better preoperative Frankel grade (p < 0.0001), and younger age (≤55 years, p = 0.0179). There were no significant differences in age, sex, tumor type, involved vertebrae level, Tomita score, intraoperative blood loss, operation time, incidence of infection, and postoperative complications between groups.
conclusionWe can improve the survival of MSCC patients with palliative decompression before motor deficits occur. After motor deficit onset, survival can still be improved with surgery within 7 days. Overall survival was better in patients aged ≤55 years.
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