ArticleMenopause (New York, N.Y.)2018
Cardiovascular and metabolic morbidity after hysterectomy with ovarian conservation: a cohort study.
Article in Menopause (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Cardiovascular outcomes after hysterectomy: a systematic review and meta-analysis.Proceedings (Baylor University. Medical Center) · 2026Pooled it
- Prevalence of cardiometabolic outcomes in women who underwent salpingo-oophorectomy to prevent hereditary breast and ovarian cancer: a meta-analysis.Familial cancer · 2024Pooled it
- Alzheimer's blood-based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.The New England journal of medicine · 2021Trial
- FIRSTT study: randomized controlled trial of uterine artery embolization vs focused ultrasound surgery.American journal of obstetrics and gynecology · 2019Trial
- [Uterine fibroids-Minimally invasive treatment with embolization].Radiologie (Heidelberg, Germany) · 2026Review
- All-cause mortality after self-reported vs. hospital-reported gynecological surgery: The HUNT study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Uterine Artery Embolisation (UAE) in Women Under 40 Years is Effective: Time to Leave Behind the Old Narrative.Cardiovascular and interventional radiology · 2026Article
- Fibroids and health disparities: the COllaboration for EQuity in Uterine Leiomyomas specialized center.American journal of obstetrics and gynecology · 2026Article
- Acute coronary syndromes across the lifespan of women.NPJ cardiovascular health · 2026Review
- Article
- The epidemiology and pathogenesis of uterine fibroids.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- Quality-of-Life Trajectories and Perceived Stress in Women Treated for Uterine Cancer: A Six-Month Prospective Study.Healthcare (Basel, Switzerland) · 2025Article
- Endometriosis: A Review.JAMA · 2025Review
- The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case-control study.Scientific reports · 2025Article
- Evaluation of the In Vivo Efficacy of the JAK Inhibitor AZD1480 in Uterine Leiomyomas Using a Patient-derived Xenograft Murine Model.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Article
- The Quality of Life beafore and after Hysterectomy in Premenopausal Women : Quality of Life in Women Before and After Hysterectomy.Galen medical journal · 2025Article
- Education level is associated with the occurrence and timing of hysterectomy: A cohort study of Canadian women.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Associations between hysterectomy and metabolic syndrome: the Multi-Ethnic Study of Atherosclerosis.American journal of obstetrics and gynecology · 2024Article
Corrections and comments
- Commented on by
- Commented on byTo the Editor.2019
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of the study was to determine the long-term risk of cardiovascular disease and metabolic conditions in women undergoing hysterectomy with bilateral ovarian conservation compared with age-matched referent women.
methodsUsing the Rochester Epidemiology Project records-linkage system, we identified 2,094 women who underwent hysterectomy with ovarian conservation for benign indications between 1980 and 2002 in Olmsted County, Minnesota. Each woman was age-matched (±1 y) to a referent woman residing in the same county who had not undergone prior hysterectomy or any oophorectomy. These two cohorts were followed historically to identify de novo cardiovascular or metabolic diagnoses. We estimated hazard ratios (HRs) and 95% CIs using Cox proportional hazards models adjusted for 20 preexisting chronic conditions and other potential confounders. We also calculated absolute risk increases and reductions from Kaplan-Meier estimates.
resultsOver a median follow-up of 21.9 years, women who underwent hysterectomy experienced increased risks of de novo hyperlipidemia (HR 1.14; 95% CI, 1.05-1.25), hypertension (HR 1.13; 95% CI, 1.03-1.25), obesity (HR 1.18; 95% CI, 1.04-1.35), cardiac arrhythmias (HR 1.17; 95% CI, 1.05-1.32), and coronary artery disease (HR 1.33; 95% CI, 1.12-1.58). Women who underwent hysterectomy at age ≤35 years had a 4.6-fold increased risk of congestive heart failure and a 2.5-fold increased risk of coronary artery disease.
conclusionsEven with ovarian conservation, hysterectomy is associated with an increased long-term risk of cardiovascular and metabolic conditions, especially in women who undergo hysterectomy at age ≤35 years. If these associations are causal, alternatives to hysterectomy should be considered to treat benign gynecologic conditions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.