Evidence map›Paper›PMID 29286922›Full record

ArticleCancer biomarkers : section A of Disease markers2018

lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma.

Chun Zhang, Xi Yang, Quan Qi, Yuhai Gao, Qiang Wei, Shuwen Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Extracellular Vesicles inInternational journal of molecular sciences · 2024
    Review
  17. HCC-Related lncRNAs: Roles and Mechanisms.International journal of molecular sciences · 2024
    Review
  18. Review
  19. Review
  20. Exosomal Long Noncoding RNAs Serve as Biomarkers for Liver Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chun ZhangDepartment of Infectious Diseases, First Hospital Affiliated to Suzhou University, Suzhou, Jiangsu 215006, China.
Xi YangDepartment of Intervention and Radiotherapy, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
Quan QiDepartment of Medical Oncology, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
Yuhai GaoDepartment of General Surgery, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
Qiang WeiDepartment of General Surgery, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
Shuwen HanDepartment of Medical Oncology, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
Huzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic hepatitis C (CHC) is a contagious liver disease that results from infection with the hepatitis C virus (HCV). The most serious consequence of CHC is HCV-related hepatocellular carcinoma (HCC).

objectiveTo illustrate the clinical significance of lncRNA HEIH expression in serum and exosomes in the development of HCV-related HCC.

methodsThirty-five CHC, twenty-two HCV-induced cirrhosis and ten HCV-related HCC patients in Huzhou Central Hospital from January 2016 to September 2016 were recruited in the present study. Basic patient information, clinical serological indicators, and clinical imaging data were investigated and analyzed. Serum samples were collected from patients after receiving informed consent. Exosomes were extracted from the serum, and electron microscopy was used to observe the ultrastructure of exosomes. Quantitative PCR was used to detect lncRNA HEIH gene expression in serum and exosomes.

resultsThe changes in the ALT, GGT, HDL, INR, Alb and AFP levels in the patients with HCV-induced cirrhosis and HCV-related HCC were statistically significant. In patients with HCV-related HCC, lncRNA-HEIH expression in serum and exosomes was increased, but the ratio of lncRNA-HEIH expression in serum versus exosomes was decreased compared to patients with CHC.

Indexed as

Biomarkers, TumorAdultBlood Coagulation TestsCarcinoma, HepatocellularExosomesFemaleHepatitis C, ChronicHumansLiver Function TestsLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedRNA, Long NoncodingBiomarkers, TumorRNA, Long NoncodingChronic hepatitis CcirrhosisexosomeHEIHhepatocellular carcinoma

Identifiers

PMID29286922
PMCPMC13078302
OpenAlexW2775859766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.