ArticleCancer biomarkers : section A of Disease markers2018
Knockdown of lncRNA GHET1 suppresses cell proliferation, invasion and LATS1/YAP pathway in non small cell lung cancer.
Article in Cancer biomarkers : section A of Disease markers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Prognostic significance of LncRNA GHET1 expression in various cancers: a systematic review and meta-analysis.Bioscience reports · 2019Pooled it
- Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers.Journal of cellular and molecular medicine · 2019Pooled it
- Prognostic value of long noncoding RNA ROR in patients with cancer in China: A systematic review and meta-analysis.Medicine · 2019Pooled it
- The Value of lncRNA GHET1 as a Prognostic Factor for Survival of Chinese Cancer Outcome: A Meta-Analysis.Disease markers · 2019Pooled it
- lncRNA H19 facilitates the proliferation and differentiation of human dental pulp stem cells via EZH2-dependent LATS1 methylation.Molecular therapy. Nucleic acids · 2021Article
- Long non-coding RNA GHET1 promotes thyroid cancer cell proliferation and invasion.Translational cancer research · 2021Article
- The significance of homeodomain transcription factor 2 in colon cancer cells.Biomedical engineering online · 2021Article
- Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma.Translational lung cancer research · 2020Article
- Genome-wide analysis of long non-coding RNA expression profile in lung adenocarcinoma compared to spinal metastasis.Annals of translational medicine · 2020Article
- The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression.Cell proliferation · 2020Review
- Long non-coding RNAs: How to regulate the metastasis of non-small-cell lung cancer.Journal of cellular and molecular medicine · 2020Review
- lncRNA USP2-AS1 promotes colon cancer progression by modulating Hippo/YAP1 signaling.American journal of translational research · 2020Article
- Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature.Frontiers in oncology · 2020Review
- Long non-coding RNA TNRC6C-AS1 promotes methylation of STK4 to inhibit thyroid carcinoma cell apoptosis and autophagy via Hippo signalling pathway.Journal of cellular and molecular medicine · 2020Article
- Clinicopathological and Prognostic Value of Gastric Carcinoma Highly Expressed Transcript 1 in Cancer: A Meta-Analysis.Journal of oncology · 2020Article
- Prognostic value of long non-coding RNA GHET1 in cancers: a systematic review and meta-analysis.Cancer cell international · 2020Review
- Long noncoding RNA MALAT1 promotes the stemness of esophageal squamous cell carcinoma by enhancing YAP transcriptional activity.FEBS open bio · 2019Article
- LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability.FEBS open bio · 2019Article
- GHET1 acts as a prognostic indicator and functions as an oncogenic lncRNA in cervical cancer.Bioscience reports · 2019Article
- The Expression ofReports of biochemistry & molecular biology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim in this study was to explore the role of long non-coding RNA GHET1 in development of non small cell lung cancer (NSCLC).
methodsLncRNA GHET1 expression levels were analyzed by qRT-PCR in tumor tissues and adjacent normal tissues in NSCLC. Measuring the cell proliferation and invasion abilities by CCK8, cell colony formation and transwell invasion assays. Relative protein expression was analyzed by western blot assays.
resultsExpression of lncRNA GHET1 was notably higher in NSCLC tissues compared with adjacent normal tissues by using qRT-PCR analyses. Higher lncRNA GHET1 expression associated with lymph node metastasis, TNM stage and showed poor outcome in NSCLC patients. Knockdown of lncRNA GHET1 suppressed cell proliferation and invasion capacity and Epithelial-Mesenchymal Transition (EMT) phenomenon of NSCLC cells. Moreover, we demonstrated that knockdown of lncRNA GHET1 suppresses LATS1/YAP pathway signaling pathway by downregulating YAP1 expression in NSCLC cells.
conclusionsGHET1 predicted a poor outcome and acted as a tumor-promoting gene in NSCLC. Thus, inhibition of GHET1 may be a potential target of NSCLC treatment.
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