ArticlePhysical review letters2017
Sequence-Dependent Persistence Length of Long DNA.
Article in Physical review letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Crowding-induced collapse and adsorption of polymers with nonuniform bending stiffness.Soft matter · 2026Article
- Massively parallel bead-free force spectroscopy with fluorescence.Science advances · 2026Article
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- Crowding-induced collapse and adsorption of polymers with nonuniform bending stiffness.bioRxiv : the preprint server for biology · 2025Article
- Collective Molecular Machines: Multidimensionality and Reconfigurability.Nano-micro letters · 2024Review
- AT-specific DNA visualization revisits the directionality of bacteriophage λ DNA ejection.Nucleic acids research · 2023Article
- Cytosine methylation regulates DNA bendability depending on the curvature.Chemical science · 2022Article
- Effect of DNA Flexibility on Complex Formation of a Cationic Nanoparticle with Double-Stranded DNA.ACS omega · 2021Article
- Mechanical Flexibility of DNA: A Quintessential Tool for DNA Nanotechnology.Sensors (Basel, Switzerland) · 2020Review
- Phosphorylated CtIP bridges DNA to promote annealing of broken ends.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Structure-mechanics statistical learning unravels the linkage between local rigidity and global flexibility in nucleic acids.Chemical science · 2020Article
- Limitations of the equivalent neutral polymer assumption for theories describing nanochannel-confined DNA.Physical review. E · 2020Article
- Building machines with DNA molecules.Nature reviews. Genetics · 2020Review
- Article
- DNA sequence-dependent chromatin architecture and nuclear hubs formation.Scientific reports · 2019Article
- Extension distribution for DNA confined in a nanochannel near the Odijk regime.The Journal of chemical physics · 2019Article
- Enzyme-free optical DNA mapping of the human genome using competitive binding.Nucleic acids research · 2019Article
- Simulations corroborate telegraph model predictions for the extension distributions of nanochannel confined DNA.Biomicrofluidics · 2019Article
- Submicrometer elasticity of double-stranded DNA revealed by precision force-extension measurements with magnetic tweezers.Science advances · 2019Article
- In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery.Science advances · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Using a high-throughput genome-mapping approach, we obtained circa 50 million measurements of the extension of internal human DNA segments in a 41 nm×41 nm nanochannel. The underlying DNA sequences, obtained by mapping to the reference human genome, are 2.5-393 kilobase pairs long and contain percent GC contents between 32.5% and 60%. Using Odijk's theory for a channel-confined wormlike chain, these data reveal that the DNA persistence length increases by almost 20% as the percent GC content increases. The increased persistence length is rationalized by a model, containing no adjustable parameters, that treats the DNA as a statistical terpolymer with a sequence-dependent intrinsic persistence length and a sequence-independent electrostatic persistence length.
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