Evidence map›Paper›PMID 29286645›Full record

ReviewChemical reviews2018

Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins.

Xiongyi Huang, John T Groves

Open access · greenAbstract readReview
In one paragraph

Review in Chemical reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 273 papers.

0numbers the graph read from it
0cells of the map it votes in
273citing papers in PubMed
26.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

273 citing papers in PubMed, 989 citations in OpenAlex.

  1. Directional Second Sphere Effect on COAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Enhancing Electrocatalytic COPrecision chemistry · 2026
    Article
  12. Empowering Precision C-H Functionalization: Advances in Peroxygenase Engineering.Angewandte Chemie (International ed. in English) · 2026
    Review
  13. Article
  14. Mimicking Extradiol Dioxygenase Reactivity on Iridium.Journal of the American Chemical Society · 2026
    Article
  15. Article
  16. Article
  17. Engineering of plant-derived P450scc forSynthetic and systems biotechnology · 2026
    Article
  18. Installing Axial Chirality by Atroposelective C(spJournal of the American Chemical Society · 2026
    Article
  19. Review
  20. Article

213 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Xiongyi HuangDepartment of Chemistry , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0001-7156-8881
John T GrovesDepartment of Chemistry , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0002-9944-5899
California Institute of Technology · USPrinceton University · US

Funding

Molecular Probes of the Mechanisms of Cytocrhome P450R37GM036298 · NIGMS · PRINCETON UNIVERSITY · PI GROVES, JOHN TAYLOR · 2007 to 2016
$3.7M
A Biocatalytic System for Enantioselective Carbon-Boron Bond FormationF32GM125231 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HUANG, XIONGYI · 2017 to 2017
$49k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM125231NIGMS NIH HHS R37 GM036298
6 · The paper itself

Abstract

As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply of metalloproteins for oxidative metabolism and protection against reactive oxygen species. Despite the diverse structures and functions of these proteins, they share common mechanistic grounds. An open-shell transition metal like iron or copper is employed to interact with O

Indexed as

HemeproteinsIronMetalloporphyrinsModels, MolecularOxygenQuantum TheoryReactive Oxygen SpeciesHemeproteinsIronMetalloporphyrinsOxygenReactive Oxygen Species

Identifiers

PMID29286645
PMCPMC5855008
OpenAlexW2778341989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.