ArticleAsian Pacific journal of cancer prevention : APJCP2017
Protein-Protein Interaction Network Analysis for a Biomarker Panel Related to Human Esophageal Adenocarcinoma
Article in Asian Pacific journal of cancer prevention : APJCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- Molecular mechanism detection of stage I to stage II transition of esophageal squamous cell carcinoma: a system biology approach.Gastroenterology and hepatology from bed to bench · 2024Article
- Network and pathway-based analysis of candidate genes associated with esophageal adenocarcinoma.Journal of gastrointestinal oncology · 2023Article
- Introducing Matrix Metalloproteinases as Crucial Targets for Intra-articular Laser Therapy in Patients with Synovial Fluid of Knee Osteoarthritis.Medical journal of the Islamic Republic of Iran · 2023Article
- Targeting colon cancer via antimicrobial RT2 peptide: a system biology study.Gastroenterology and hepatology from bed to bench · 2023Article
- A systemic study on the vulnerability and fatality of prostate cancer patients towards COVID-19 through analysis of the TMPRSS2, CXCL10 and their co-expressed genes.Genomics & informatics · 2022Article
- Prediction of Genes Involved in Lung Cancer with a Systems Biology Approach Based on Comprehensive Gene Information.Biochemical genetics · 2022Review
- Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis.Journal of lasers in medical sciences · 2022Article
- Introducing critical common dysregulated proteins in esophageal, gastric, and intestinal cancers.Gastroenterology and hepatology from bed to bench · 2022Article
- Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes.Current research in microbial sciences · 2021Article
- GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses.Scientific reports · 2021Article
- Identification ofCell journal · 2021Article
- Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis.Archives of academic emergency medicine · 2021Article
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5 authors.
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Abstract
Background: Esophageal adenocarcinoma (EAC) is one of the mostlethal cancers in the world with a very poor prognosis. Identification of molecular diagnostic methods is an important goal. Since protein-protein interaction (PPI) network analysis is a suitable method for molecular assessment, in the present research a PPI network related to EAC was targeted. Material and Method: Cytoscape software and its applications including STRING DB, Cluster ONE and ClueGO were applied to analyze the PPI network. Result: Among 182 EAC-related proteins which were identified, 129 were included in a main connected component. Proteins based on centrality analysis of characteristics such as degree, betweenness, closeness and stress were screened and key nodes were introduced. Two clusters were determined of which only one was significant statistically. Gene ontology revealed 50 terms in three groups associated with EAC. Conclusion: The findings indicate nine crucial proteins could form a candidate biomarker panel for EAC. Furthermore, an important cluster with 27 proteins related to the disease was identified. Gene ontology analysis of this cluster showed main related terms to closely correspond with those for colorectal cancer.
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