Trial reportThe Journal of clinical psychiatry
Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
Trial report in The Journal of clinical psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00809835 (Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse With Methadone Maintained Individuals), which is not on this map. Cited by 44 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse With Methadone Maintained Individuals
Who cites it
44 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Digitally Delivered Cognitive Behavioral Interventions for Alcohol and Other Drug Use: Meta-Analysis Across Consumption and Psychosocial Outcomes.JMIR mental health · 2026Pooled it
- Efficacy of cognitive behavioral therapy for stimulant use disorders: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Exploring the efficacy of cholinergic agents for the treatment of psychostimulant use disorder: a systematic review.Psychopharmacology · 2024Pooled it
- Psychosocial interventions for stimulant use disorder.The Cochrane database of systematic reviews · 2024Pooled it
- Change in employment status and cocaine use treatment outcomes: A secondary analysis across six clinical trials.Journal of substance abuse treatment · 2019Pooled it
- Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race.Journal of substance abuse treatment · 2019Pooled it
- Digital Cognitive Behavioral Therapy Reduces Heavy Drinking Among a Non-Treatment Sample of People With Alcohol Use Disorder: A Feasibility Trial With CBT4CBT.Alcohol, clinical & experimental research · 2026Trial
- A randomized controlled trial to assess whether a telehealth-based contingency management intervention reduces alcohol use for individuals with alcohol use disorder.Contemporary clinical trials · 2025Trial
- The role of Iowa gambling task performance in response to citalopram treatment for cocaine use disorder.The American journal of drug and alcohol abuse · 2025Trial
- Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence.Journal of substance use and addiction treatment · 2024Trial
- Evaluating a longitudinal mediation model of perceived stress, depressive symptoms, and substance use treatment outcomes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Trial
- Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder.Journal of substance abuse treatment · 2019Trial
- Double-Blind Placebo-Controlled Trial of Galantamine for Methadone-Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use.The American journal on addictions · 2019Trial
- Feasibility and effects of galantamine on cognition in humans with cannabis use disorder.Pharmacology, biochemistry, and behavior · 2019Trial
- Randomized pilot trial of Web-based cognitive-behavioral therapy adapted for use in office-based buprenorphine maintenance.Substance abuse · 2019Trial
- Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.American journal of public health · 2018Trial
- Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes.The American journal of psychiatry · 2018Trial
- Testing measurement invariance of the Brief Symptom Inventory across race, sex, and time among adults with cocaine use disorder.Psychological assessment · 2026Article
- Complementary services improve recovery outcomes among college students with alcohol or other drug related use disorders.Scientific reports · 2026Article
- Comparing content within a culturally-adapted digital treatment for Hispanic patients with alcohol use disorder.NPJ digital medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo examine whether galantamine, a cognitive-enhancing medication that is both acetylcholinesterase inhibitor and agonist at nicotinic acetylcholine receptors, is effective at improving cocaine use outcomes and cognitive functioning, alone and in combination with computerized cognitive behavioral therapy (CBT).
methodA 12-week, randomized 2 × 2, factorial trial was conducted to evaluate galantamine versus placebo (double-blind) and computerized CBT plus standard methadone treatment versus standard methadone treatment alone in a community-based methadone maintenance program (September 2009-April 2015). One hundred twenty individuals diagnosed with DSM-IV cocaine use disorder were randomly assigned to the following conditions: (1) galantamine (8 mg/d) plus standard methadone maintenance treatment (treatment as usual [TAU]), (2) placebo plus TAU, (3) galantamine plus computerized CBT plus TAU, or (4) placebo plus computerized CBT plus TAU; medication administration was supervised at the time of daily methadone dosing. The primary cocaine use outcome was change in percent days of abstinence over time. Number of cocaine-negative urine toxicology screens submitted and cognitive function were secondary outcomes.
resultsRandom effect regression analysis indicated significant reductions in frequency of cocaine use over time, with significant treatment-by-time effects for both galantamine over placebo (F = 5.3, P = .02, d = 0.34) and computerized CBT over standard methadone treatment (F = 4.2, P = .04, d = 0.30) but no evidence of significant benefit of the combination over either treatment alone. Pretreatment to posttreatment comparisons of multiple indices of cognitive functioning, including sustained attention, indicated no benefit of galantamine over placebo.
conclusionsFindings suggest benefits of galantamine and computerized CBT for reducing cocaine use in this sample. Although galantamine did not improve measures of cognitive function in this sample, multiple measures of cognitive function were associated with cocaine use outcomes, underlining the significance of cognitive function in cocaine treatment outcomes.
trial registrationClinicalTrials.gov identifier: NCT00809835.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.