Evidence map›Paper›PMID 29286560›Full record

Trial reportPediatric blood & cancer2018

Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia.

Cheryl L Cox, Liang Zhu, Sue C Kaste, Kumar Srivastava, Linda Barnes, Paul C Nathan, Robert J Wells, Kirsten K Ness

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric blood & cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Nutrition and physical activity interventions delivered to children and young people during cancer treatment: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  3. Bone mineral density in childhood cancer survivors during and after oncological treatment: A systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheryl L CoxDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-0625-328X
Liang ZhuDepartment of Biostatistics, The University of Texas Health Science Center at Houston, Houston, Texas.
Sue C KasteDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Kumar SrivastavaDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Linda BarnesDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Paul C NathanThe Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Robert J WellsDivision of Pediatrics-Unit 87, MD Anderson Cancer Center, Houston, Texas.
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.

Funding

Physical Activity to Modify Sequelae and QOL in Childhood ALL: A Nursing TrialR01CA129384 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI COX, CHERYL LORANE · 2009 to 2013
$4.3M
NCI NIH HHS R01 CA129384
6 · The paper itself

Abstract

backgroundThe early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm PROCEDURE: A 2.5-year randomized controlled trial of 73 patients aged 4-18.99 years within 10 days of ALL diagnosis assessed BMD at baseline (T

resultsThere were no significant changes between groups (intervention, n = 33; usual care, n = 40) in BMD (P = 0.059) at T

conclusionsThe intervention delivered during treatment was not successful in modifying BMD, physical function, or HRQL. Physical activity, at the level and intensity required to modify these factors, may not be feasible during early treatment owing to the child's responses to the disease and treatment. Future studies will consider intervention implementation during late maintenance therapy, extending into survivorship.

Indexed as

Muscle StrengthPhysical EndurancePhysical Therapy ModalitiesQuality of LifeRange of Motion, ArticularAdolescentAdultBone DensityChildChild, PreschoolFemaleHumansMalePrecursor Cell Lymphoblastic Leukemia-Lymphomabone mineral densityhealth-related quality of lifelate effectspediatric acute lymphoblastic leukemiaphysical function

Identifiers

PMID29286560
PMCPMC5821547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.