Evidence map›Paper›PMID 29286361›Full record

ArticleJournal of visualized experiments : JoVE2017

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model.

Cara L Haymaker, Yared Hailemichael, Yi Yang, Roza Nurieva

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Cara L HaymakerDepartment of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center.
Yared HailemichaelDepartment of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center.
Yi YangDepartment of Immunology, University of Texas MD Anderson Cancer Center; Department of Radiation Oncology, The Second Hospital of Jilin University.
Roza NurievaDepartment of Immunology, University of Texas MD Anderson Cancer Center; rnurieva@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USSecond Affiliated Hospital of Jilin University · CN

Funding

STAT1: New regulator of inflammatory Th17 and Th2 cellsR21AI120012 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2016 to 2017
$440k
Role of Cul4A in Th2 tolerance and airway inflammationR56AI125269 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2017 to 2017
$300k
Role of Grail in maintaining humoral immune toleranceR03AI120027 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2015 to 2016
$160k
Grail-targeting breaks the immune tolerance to melanomaR03CA219760 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2017 to 2018
$160k
NCI NIH HHS R03 CA219760NIAID NIH HHS R03 AI120027NIAID NIH HHS R21 AI120012NIAID NIH HHS R56 AI125269
6 · The paper itself

Abstract

Current methodologies for antigen-specific killing are limited to in vitro use or utilized in infectious disease models. However, there is not a protocol specifically intended to measure antigen-specific killing without an infection. This protocol is designed and describes methods to overcome these limitations by allowing for the detection of antigen-specific killing of a target cell by CD8

Indexed as

AntigensCD8-Positive T-LymphocytesEpitopes, T-LymphocyteFlow CytometryHumansT-LymphocytesVaccinationAntigensEpitopes, T-Lymphocyte

Identifiers

PMID29286361
PMCPMC5755481
OpenAlexW2769719113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.