Evidence map›Paper›PMID 29286346›Full record

ArticleMolecules (Basel, Switzerland)2017

Hydrazone Derivatives Enhance Antileishmanial Activity of Thiochroman-4-ones.

Esteban Vargas, Fernando Echeverri, Yulieth A Upegui, Sara M Robledo, Wiston Quiñones

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Antileishmanial Activity and In Silico Molecular Docking Studies ofTropical medicine and infectious disease · 2023
    Article
  8. Chromanone-A Prerogative Therapeutic Scaffold: An Overview.Arabian journal for science and engineering · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Alkyl and Aryl Derivatives Based onMolecules (Basel, Switzerland) · 2020
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Esteban VargasQuímica Orgánica de Productos Naturales, Instituto de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 No. 52-21, Medellín A. A 1226, Colombia. esteban.vargasc@udea.edu.co.ORCID 0000-0001-7801-2202
Fernando EcheverriQuímica Orgánica de Productos Naturales, Instituto de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 No. 52-21, Medellín A. A 1226, Colombia. fernando.echeverri@udea.edu.co.
Yulieth A UpeguiPECET-Programa de Estudio y Control de Enfermedades Tropicales. Facultad de Medicina, Universidad de Antioquia, Calle 70 No. 52-21, Medellín A. A 1226, Colombia. yulexa1@gmail.com.
Sara M RobledoPECET-Programa de Estudio y Control de Enfermedades Tropicales. Facultad de Medicina, Universidad de Antioquia, Calle 70 No. 52-21, Medellín A. A 1226, Colombia. sara.robledo@udea.edu.co.ORCID 0000-0003-2752-4931
Wiston QuiñonesQuímica Orgánica de Productos Naturales, Instituto de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Calle 70 No. 52-21, Medellín A. A 1226, Colombia. wiston.quinones@udea.edu.co.
Universidad de Antioquia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous leishmaniasis (CL) is a neglected tropical disease, which causes severe skin lesions. Due to the lack of effective vaccines, and toxicity or reduced effectiveness of available drugs in addition to complex and prolonged treatments, there is an urgent need to develop alternatives for the treatment for CL with different mechanisms of action. In our effort to search for new promising hits against

Indexed as

Antiprotozoal AgentsCell DeathChromansFlavanonesHumansHydrazonesLeishmaniaMonocytesAntiprotozoal AgentsChromansFlavanonesHydrazonesthioflavanoneacyl hydrazonecytotoxicityLeishmaniathiochroman-4-ones

Identifiers

PMID29286346
PMCPMC6017792
OpenAlexW2768313364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.