ArticleMolecular medicine reports2018
Treatment with Shuyu capsule increases 5-HT1AR level and activation of cAMP-PKA-CREB pathway in hippocampal neurons treated with serum from a rat model of depression.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan (Liver) Depression and Qi Stagnation Syndrome: A Randomized, Double-Blind, Multicenter, Phase-II Clinical Trial.Chinese journal of integrative medicine · 2024Trial
- Profiles of Circulating Exosomal microRNAs in Female College Students with Qi Stagnation and Balanced Constitutions by High-Throughput Sequencing.Combinatorial chemistry & high throughput screening · 2026Article
- Shuyu capsule improves estrous cycle-dependent depression-like behavior in premenstrual dysphoric disorder (PMDD) mice by increasing GABAergic neuronal activation and downregulating GABAJournal of Zhejiang University. Science. B · 2025Article
- Alterations in gray matter volume and associated transcriptomics after electroconvulsive therapy in major depressive disorder.Psychological medicine · 2025Article
- Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats.The international journal of neuropsychopharmacology · 2024Article
- Article
- Chronic mild stress induces differential depression-like symptoms and c-Fos and 5HT1A protein levels in high-anxiety female Long Evans rats.Behavioural brain research · 2023Article
- Article
- A Pattern to Link Adenosine Signaling, Circadian System, and Potential Final Common Pathway in the Pathogenesis of Major Depressive Disorder.Molecular neurobiology · 2022Review
- Mathematical algorithm-based identification of the functional components and mechanisms in depression treatment: An example of Danggui-Shaoyao-San.Frontiers in cell and developmental biology · 2022Article
- Potential therapeutic effect and methods of traditional Chinese medicine on COVID-19-induced depression: A review.Anatomical record (Hoboken, N.J. : 2007) · 2021Review
- Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.Journal of neuroinflammation · 2021Article
- Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters.Food science & nutrition · 2021Article
- Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Zhi-Zi-Hou-Po Decoction in Depression.Frontiers in pharmacology · 2021Article
- MicroRNA-345-5p regulates depression by targeting suppressor of cytokine signaling 1.Brain and behavior · 2020Article
- Weighted Gene Coexpression Network Analysis Identifies Specific Modules and Hub Genes Related to Major Depression.Neuropsychiatric disease and treatment · 2020Article
- Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- SiNiSan Ameliorates the Depression-Like Behavior of Rats That Experienced Maternal Separation Through 5-HT1A Receptor/CREB/BDNF Pathway.Frontiers in psychiatry · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depressive disorder (DD) is one of the typical affective disorders with a high morbidity, high suicide rate and high recurrence rate. Dysfunction of the 5‑hydroxytryptamine 1A receptor (5‑HT1AR) in the brain may serve an important role in the pathogenesis of DD. Currently, selective serotonin reuptake inhibitors are the first line antidepressants with 60‑70% efficacy and severe adverse effects. Previous studies have demonstrated that Chinese herbal medicines, including the Shuyu capsule (SYC), are effective antidepressants with few side effects. However, the mechanism remains unclear. In the present study, the effects of the SYC on the 5‑HT1AR level and the activation of adenylyl cyclase‑cyclic adenosine monophosphate (cAMP)‑protein kinase A (PKA)‑cAMP response element‑binding (CREB) signaling pathway that 5‑HT1AR mediates in the cells of hippocampal neurons were investigated in vitro. The SYC demonstrated an antidepressant effect similar to that of fluoxetine in a rat depression model. Treatment of hippocampal neurons with the serum of depressive rats resulted in a decrease in the 5‑HT1AR protein level and the activation of the cAMP‑PKA‑CREB signaling pathway in hippocampal neurons. Exposure to the serum of rats that received chronic mild stress plus SYC treatment led to no alterations in the 5‑HT1AR level or the activation of the cAMP‑PKA‑CREB signaling pathway compared with those of cells exposed to normal rat serum. This effect is similar to the effects of 5‑HT1AR antagonist WAY‑100635. In addition, the 5‑HT1A agonist 8‑hydroxy‑(dipropylamino) tetralin did not antagonize the effects of the SYC. Furthermore, the SYC exhibited an increased effect compared with fluoxetine on 5‑HT1AR levels and CREB activation. The present study suggested that the SYC functions by increasing 5‑HT1AR protein levels and the activation of the 5‑HT1AR‑mediated cAMP‑PKA‑CREB signaling pathway in hippocampal neurons.
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