Evidence map›Paper›PMID 29286088›Full record

ArticleInternational journal of molecular medicine2018

Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis.

Fei Hou, Ruixia Liu, Xiaoya Liu, Lijian Cui, Xiaozheng Yu, Yan Wen, Huiguo Ding, Chenghong Yin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fei HouDepartment of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Ruixia LiuDepartment of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Xiaoya LiuDepartment of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Lijian CuiDepartment of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Xiaozheng YuDepartment of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Yan WenDepartment of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Huiguo DingGastroenterology and Hepatology Department, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P.R. China.
Chenghong YinDepartment of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, P.R. China.
Capital Medical University · CNBeijing Friendship Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arkadia is able to degrade key signaling molecules in the transforming growth factor (TGF)‑β1 signaling pathway; however, the expression of Arkadia in the liver during development and progression of TGF‑β1/Smad signaling‑regulated hepatic fibrosis remains to be elucidated. The present study aimed to examine Arkadia expression in the livers of two rat models of hepatic fibrosis induced by bile duct ligation and carbon tetrachloride intoxication, and in human liver samples from patients with hepatic fibrosis. Expression was analyzed by quantitative polymerase chain reaction, immunohistochemistry and western blot analysis. The results indicated that Arkadia was predominantly expressed in the cytoplasm of cholangiocytes and hepatocytes. The protein expression levels of Arkadia were significantly decreased in fibrotic livers, whereas the mRNA expression levels of Arkadia were significantly increased in fibrotic livers compared with in nonfibrotic livers. In conclusion, these data indicated that Arkadia may regulate the pathogenesis and progression of hepatic fibrosis.

Indexed as

Disease ProgressionAdultAnimalsBile DuctsCarbon TetrachlorideFemaleHumansLigationLiverLiver CirrhosisMaleNuclear ProteinsRats, WistarUbiquitin-Protein LigasesYoung AdultCarbon TetrachlorideNuclear ProteinsRNF111 protein, humanRnf111 protein, ratUbiquitin-Protein Ligases

Identifiers

PMID29286088
PMCPMC5819942
OpenAlexW2775843613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.