Evidence map›Paper›PMID 29285679›Full record

ArticleTranslational stroke research2018

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model.

Robin L Webb, Erin E Kaiser, Shelley L Scoville, Tyler A Thompson, Sumbul Fatima, Chirayukumar Pandya, Karishma Sriram, Raymond L Swetenburg, Kumar Vaibhav, Ali S Arbab and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 2 syntheses or guidelines pooled it, 277 citations in OpenAlex.

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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Robin L WebbArunA Biomedical, Athens, GA, 30602, USA.
Erin E KaiserRegenerative Bioscience Center, Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, 30602, USA.
Shelley L ScovilleArunA Biomedical, Athens, GA, 30602, USA.
Tyler A ThompsonArunA Biomedical, Athens, GA, 30602, USA.
Sumbul FatimaDepartment of Medical Laboratory, Imaging, and Radiologic Sciences, Augusta University, Augusta, GA, 30912, USA.
Chirayukumar PandyaDepartment of Medical Laboratory, Imaging, and Radiologic Sciences, Augusta University, Augusta, GA, 30912, USA.
Karishma SriramRegenerative Bioscience Center, Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, 30602, USA.
Raymond L SwetenburgArunA Biomedical, Athens, GA, 30602, USA.
Kumar VaibhavDepartment of Medical Laboratory, Imaging, and Radiologic Sciences, Augusta University, Augusta, GA, 30912, USA.
Ali S ArbabCancer Center, Augusta University, Augusta, GA, 30912, USA.
Babak BabanDepartment of Oral Biology, Dental College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Krishnan M DhandapaniDepartment of Neurosurgery, Augusta University, Augusta, GA, 30912, USA.
David C HessDepartment of Neurology, Augusta University, Augusta, GA, 30912, USA.
M N HodaDepartment of Medical Laboratory, Imaging, and Radiologic Sciences, Augusta University, Augusta, GA, 30912, USA.
Steven L SticeArunA Biomedical, Athens, GA, 30602, USA. sstice@arunabiomedical.com.
Augusta University · USAruna Biomedical (United States) · USUniversity of Georgia · USAugusta University Health · US

Funding

National Science Foundation CBET-0939511
6 · The paper itself

Abstract

Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be attributed in part to limited and isolated testing often solely in "young" rodent models and focusing on a single secondary injury mechanism. Here, extracellular vesicles (EVs), nanometer-sized cell signaling particles, were tested in a mouse thromboembolic (TE) stroke model. Neural stem cell (NSC) and mesenchymal stem cell (MSC) EVs derived from the same pluripotent stem cell (PSC) line were evaluated for changes in infarct volume as well as sensorimotor function. NSC EVs improved cellular, tissue, and functional outcomes in middle-aged rodents, whereas MSC EVs were less effective. Acute differences in lesion volume following NSC EV treatment were corroborated by MRI in 18-month-old aged rodents. NSC EV treatment has a positive effect on motor function in the aged rodent as indicated by beam walk, instances of foot faults, and strength evaluated by hanging wire test. Increased time with a novel object also indicated that NSC EVs improved episodic memory formation in the rodent. The therapeutic effect of NSC EVs appears to be mediated by altering the systemic immune response. These data strongly support further preclinical development of a NSC EV-based stroke therapy and warrant their testing in combination with FDA-approved stroke therapies.

Indexed as

Age FactorsAnimalsAntigens, CDCell- and Tissue-Based TherapyCell MovementDisease Models, AnimalExtracellular VesiclesHindlimb SuspensionHumansInfarction, Middle Cerebral ArteryMesenchymal Stem CellsMiceNeural Stem CellsPsychomotor PerformanceRecovery of FunctionStrokeAntigens, CDNeural stem cell extracellular vesiclesPreclinical stroke modelThromboembolic stroke

Identifiers

PMID29285679
PMCPMC6132936
OpenAlexW2777343869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.