ArticleInterface focus2018
Subject-specific multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease.
Article in Interface focus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 66 citations in OpenAlex.
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Linking dietary patterns to Alzheimer's disease biomarkers with network mathematical modeling could enable new approach methodologies in preventative AD research: a narrative interdisciplinary review.Frontiers in nutrition · 2025Review
- A Posteriori Error Analysis for a Coupled Stokes-Poroelastic System with Multiple Compartments.Journal of scientific computing · 2025Article
- Computational Fluid Dynamics of Cerebrospinal Fluid.Advances in experimental medicine and biology · 2024Review
- MPETDrug delivery · 2023Article
- Why Intracranial Compliance Is Not Utilized as a Common Practical Tool in Clinical Practice.Biomedicines · 2023Review
- Are brain displacements and pressures within the parenchyma induced by surface pressure differences? A computational modelling study.PloS one · 2023Article
- Article
- Human intracranial pulsatility during the cardiac cycle: a computational modelling framework.Fluids and barriers of the CNS · 2022Article
- Influence of interaction of cerebral fluids on ventricular deformation: A mathematical approach.PloS one · 2022Article
- On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation.Annals of biomedical engineering · 2021Article
- Poroelastic Mechanical Properties of the Brain Tissue of Normal Pressure Hydrocephalus Patients During Lumbar Drain Treatment Using Intrinsic Actuation MR Elastography.Academic radiology · 2021Article
- A porous circulation model of the human brain forInterface focus · 2021Article
- Exploring neurodegenerative disorders using a novel integrated model of cerebral transport: Initial results.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2020Article
- Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields.Fluids and barriers of the CNS · 2019Article
- On the Validation of a Multiple-Network Poroelastic Model Using Arterial Spin Labeling MRI Data.Frontiers in computational neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is emerging evidence suggesting that Alzheimer's disease is a vascular disorder, caused by impaired cerebral perfusion, which may be promoted by cardiovascular risk factors that are strongly influenced by lifestyle. In order to develop an understanding of the exact nature of such a hypothesis, a biomechanical understanding of the influence of lifestyle factors is pursued. An extended poroelastic model of perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and cerebral blood flow variability is used. The subject-specific datasets used in the modelling of this paper were collected as part of prospective data collection. Two cases were simulated involving male, non-smokers (control and mild cognitive impairment (MCI) case) during two states of activity (high and low). Results showed a marginally reduced clearance of cerebrospinal fluid (CSF)/interstitial fluid (ISF), elevated parenchymal tissue displacement and CSF/ISF accumulation and drainage in the MCI case. The peak perfusion remained at 8 mm s
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.