Evidence map›Paper›PMID 29285235›Full record

ArticleOncotarget2017

Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.

Joshua Jiawei Zhou, Yuanshen Huang, Xue Zhang, Yabin Cheng, Liren Tang, Xiaodong Ma

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Genetic research progress in branchioZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  5. The multi-functional eyes absent proteins.Critical reviews in biochemistry and molecular biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Joshua Jiawei ZhouDepartment of Anesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Yuanshen HuangDepartment of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
Xue ZhangDepartment of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
Yabin ChengSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Liren TangWelichem Biotech Inc., Burnaby, BC, Canada.
Xiaodong MaCollege of Pharmacology, Dalian Medical University, Dalian, Liaoning Province, China.
University of British Columbia · CADalian Medical University · CNWelichem Biotech (Canada) · CAXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

EYA1 is a DNA repair enzyme that is induced after DNA damage and is upregulated in melanoma. However, its role in pathogenesis and therapeutic targeting of melanoma is unknown. Our objectives are (1) to study the relationship between EYA1 expression levels and melanoma patients' clinical pathologic parameters including survival; (2) to investigate its impact on cultured melanoma cells

Indexed as

benzbromaronebiomarkerchromatin remodelingEYA1melanoma

Identifiers

PMID29285235
PMCPMC5739622
OpenAlexW2758153481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.