Evidence map›Paper›PMID 29285137›Full record

ArticleExperimental and therapeutic medicine2017

Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.

Yi-Peng Gu, Xiao-Mei Yang, Zhen-Hua Duan, Ping Luo, Jiang-Hua Shang, Wei Xiao, Ye-Xing Tao, Da-Yan Zhang, Yun-Bo Zhang, Hua-Zhong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Polysaccharides fromCurrent medicinal chemistry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi-Peng GuInstitute of Food Research, Hezhou University, Hezhou, Guangxi 542899, P.R. China.
Xiao-Mei YangInstitute of Food Research, Hezhou University, Hezhou, Guangxi 542899, P.R. China.
Zhen-Hua DuanInstitute of Food Research, Hezhou University, Hezhou, Guangxi 542899, P.R. China.
Ping LuoDepartment of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China.
Jiang-Hua ShangGuangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning, Guangxi 530001, P.R. China.
Wei XiaoDepartment of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China.
Ye-Xing TaoDepartment of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China.
Da-Yan ZhangDepartment of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China.
Yun-Bo ZhangDepartment of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China.
Hua-Zhong LiuDepartment of Applied Chemistry, College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to determine the mechanisms driving the protective effects of squid ink polysaccharide (SIP) against cyclophosphamide (CP)-induced testicular damage, focusing on germ cells. In the testes of mice exposed to CP and/or SIP, the present study examined the levels of reactive oxygen species (ROS) and malondialdehyde, activity of superoxide dismutase levels, protein expression levels of B-cell lymphoma 2 (Bcl2), Bcl2-associated X protein (Bax), and total Caspase 3, activation of p-p38 and p-Akt proteins, and tissue morphology. The findings indicated that CP induced ROS production and oxidative stress, resulting in testicular damage. However, under administration of SIP, oxidative stress was impaired and the testicular toxicity induced by CP was weakened, which implied that SIP may have an important role in preventing chemotherapeutic damage to the male reproductive system via promoting antioxidant ability. Furthermore, the altered expression levels, including the upregulation of Bax and Caspase 3, downregulation of Bcl-2 and the increased Bax/Bcl-2 ratio, indicated that apoptosis occurred in CP exposed testes of mice; however, the alterations were reversed in mice treated with SIP. Moreover, in CP-exposed testes, p38 and Akt proteins were significantly phosphorylated (P<0.05), whereas in the testes of mice co-treated with SIP and CP, phosphorylation of the two proteins was inhibited, demonstrating that the two signalling pathways participated in the regulative processes of the deleterious effects caused by CP, and the preventive effects SIP mediated.

Indexed as

apoptosiscyclophosphamidesquid ink polysaccharidetesticular germ cells

Identifiers

PMID29285137
PMCPMC5740781

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.